氧化应激与社区居住男性和透析男性勃起功能障碍的关系。

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2022-12-01 DOI:10.1080/13685538.2022.2103113

Naoki Fujita, Masaki Momota, Mizuri Ishida, Takuro Iwane, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Kazuaki Yoshikawa, Kanemitsu Yamaya, Chikara Ohyama

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引用次数: 0

摘要

目的:探讨社区居住男性和透析男性中氧化应激与勃起功能障碍(ED)的关系。方法:本横断面研究包括398名社区居住男性和42名透析男性。采用8-羟基-2'-脱氧鸟苷(8-OHdG)评价氧化应激。结果:Spearman秩相关检验显示，社区男性尿液8-OHdG水平与5项国际勃起功能指数评分(ρ = -0.005, p = 0.917)之间无显著相关性，透析男性血浆8-OHdG水平与男性性健康量表评分之间无显著相关性(ρ = 0.166, p = 0.295)。在社区男性中，单变量和多变量分析显示尿8-OHdG水平与ED无显著相关(优势比[OR]: 1.005, 95%可信区间[CI]: 0.884-1.144, p = 0.934;OR: 0.930, 95% CI: 0.798-1.084, p = 0.353;分别)。在接受透析的男性中，单变量分析显示血浆8-OHdG水平与严重ED无显著相关性(OR: 0.967, 95% CI: 0.876-1.066, p = 0.498)。结论:氧化应激与社区居住男性和透析男性的ED患病率和严重程度无显著相关。

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Association of oxidative stress with erectile dysfunction in community-dwelling men and men on dialysis.

Objectives: To investigate the association between oxidative stress and erectile dysfunction (ED) in community-dwelling men and men on dialysis.

Methods: This cross-sectional study included 398 community-dwelling men and 42 men on dialysis. Oxidative stress was assessed using 8-hydroxy-2'-deoxyguanosine (8-OHdG). Univariable and multivariable logistic regression analyses were performed to evaluate the association between oxidative stress and ED.

Results: Spearman's rank correlation test showed no significant correlation between urine 8-OHdG levels and the 5-Item International Index of Erectile Function scores in community-dwelling men (ρ = -0.005, p = 0.917) and between plasma 8-OHdG levels and the Sexual Health Inventory for Men scores in men on dialysis (ρ = 0.166, p = 0.295). In community-dwelling men, univariable and multivariable analyses revealed that urine 8-OHdG level was not significantly associated with ED (odds ratio [OR]: 1.005, 95% confidence interval [CI]: 0.884-1.144, p = 0.934; OR: 0.930, 95% CI: 0.798-1.084, p = 0.353; respectively). In men on dialysis, univariable analyses revealed that plasma 8-OHdG level was not significantly associated with severe ED (OR: 0.967, 95% CI: 0.876-1.066, p = 0.498).

Conclusions: Oxidative stress was not significantly associated with ED prevalence and severity in community-dwelling men and men on dialysis.

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来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.