{"title":"探索蒲冈野提取物对糖尿病治疗的潜力:系统回顾和荟萃分析。","authors":"Sry Suryani Widjaja, Rusdiana Rusdiana, Lowilius Wiyono","doi":"10.5455/medarh.2022.76.292-296","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Poguntano (<i>Picria fel-terrae Merr</i>) is a traditional herb commonly used as a blood glucose lowering agent in Indonesia. However, the effectiveness of the herb has not yet been established.</p><p><strong>Objective: </strong>This systematic review and meta-analysis aim to review the hypoglycemic effect of Poguntano extract in lowering plasma glucose levels.</p><p><strong>Methods: </strong>We conducted a literature search using peer-reviewed databases for relevant articles on Poguntano extract in animal models of diabetes. The effect size was pooled using a random effect model.</p><p><strong>Results: </strong>Two animal studies were included in the systematic review and meta-analysis. There was a significant difference in plasma glucose levels between diabetic control and rats treated with Puguntano extract (MD: 28.77; 95%CI: 6.20-51.34; p=0.01). There was no significant difference between non-diabetic control and Poguntano extract.</p><p><strong>Conclusion: </strong>Poguntano extract lowers the blood glucose levels in diabetic rats compared to control.</p>","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"76 4","pages":"292-296"},"PeriodicalIF":0.0000,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/43/e9/medarch-76-292.PMC9559780.pdf","citationCount":"0","resultStr":"{\"title\":\"Exploring the Potential of Poguntano Extract on Diabetes Management: Systematic Review and Meta-Analysis.\",\"authors\":\"Sry Suryani Widjaja, Rusdiana Rusdiana, Lowilius Wiyono\",\"doi\":\"10.5455/medarh.2022.76.292-296\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Poguntano (<i>Picria fel-terrae Merr</i>) is a traditional herb commonly used as a blood glucose lowering agent in Indonesia. However, the effectiveness of the herb has not yet been established.</p><p><strong>Objective: </strong>This systematic review and meta-analysis aim to review the hypoglycemic effect of Poguntano extract in lowering plasma glucose levels.</p><p><strong>Methods: </strong>We conducted a literature search using peer-reviewed databases for relevant articles on Poguntano extract in animal models of diabetes. The effect size was pooled using a random effect model.</p><p><strong>Results: </strong>Two animal studies were included in the systematic review and meta-analysis. There was a significant difference in plasma glucose levels between diabetic control and rats treated with Puguntano extract (MD: 28.77; 95%CI: 6.20-51.34; p=0.01). There was no significant difference between non-diabetic control and Poguntano extract.</p><p><strong>Conclusion: </strong>Poguntano extract lowers the blood glucose levels in diabetic rats compared to control.</p>\",\"PeriodicalId\":18421,\"journal\":{\"name\":\"Medicinski arhiv\",\"volume\":\"76 4\",\"pages\":\"292-296\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/43/e9/medarch-76-292.PMC9559780.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicinski arhiv\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5455/medarh.2022.76.292-296\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicinski arhiv","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5455/medarh.2022.76.292-296","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Exploring the Potential of Poguntano Extract on Diabetes Management: Systematic Review and Meta-Analysis.
Background: Poguntano (Picria fel-terrae Merr) is a traditional herb commonly used as a blood glucose lowering agent in Indonesia. However, the effectiveness of the herb has not yet been established.
Objective: This systematic review and meta-analysis aim to review the hypoglycemic effect of Poguntano extract in lowering plasma glucose levels.
Methods: We conducted a literature search using peer-reviewed databases for relevant articles on Poguntano extract in animal models of diabetes. The effect size was pooled using a random effect model.
Results: Two animal studies were included in the systematic review and meta-analysis. There was a significant difference in plasma glucose levels between diabetic control and rats treated with Puguntano extract (MD: 28.77; 95%CI: 6.20-51.34; p=0.01). There was no significant difference between non-diabetic control and Poguntano extract.
Conclusion: Poguntano extract lowers the blood glucose levels in diabetic rats compared to control.
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