ALEX与ISAC多重阵列分析特应性儿童食物过敏。

Q2 Medicine

Clinical and Molecular Allergy Pub Date : 2022-08-27 DOI:10.1186/s12948-022-00177-w

Laura J H Sonneveld, Joyce A M Emons, Nicolette J T Arends, Lonneke J Landzaat, Sharon Veenbergen, Marco W J Schreurs

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引用次数: 1

摘要

ALEX多重阵列是一种较新的多重过敏试验，可分析120多种过敏原提取物和170多种分子成分。ISAC是迄今为止使用和研究最多的多路阵列，提供112个分子组分。在10名患有多种食物过敏的特应性儿童中，ALEX和ISAC sIgE结果在几乎所有共同的食物成分上都有很好的一致性。ALEX中大量过敏原的存在可以帮助临床医生改善个性化的饮食建议。然而，ALEX发现了更多临床相关性未知的阳性致敏反应，这可能会增加临床复杂性。儿科过敏症医生应该意识到这一点，特别是在患有(严重)湿疹的年轻特应性儿童中，他们还没有引入各种食物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

ALEX versus ISAC multiplex array in analyzing food allergy in atopic children.

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ALEX versus ISAC multiplex array in analyzing food allergy in atopic children.

ALEX multiplex array is a relatively new multiplex allergy test which analyses more than 120 allergen extracts and 170 molecular components. ISAC is the most used and studied multiplex array to date, offering 112 molecular components. In ten atopic children with multiple food allergies good agreement was observed between ALEX and ISAC sIgE results for nearly all shared food components. Presence of larger number of allergens in ALEX could help clinicians to improve personalized dietary advice. However more positive sensitizations with unknown clinical relevance were found by ALEX, potentially increasing clinical complexity. Pediatric allergists should be aware of this, especially in young atopic children with (severe) eczema who have not introduced all sorts of food yet.

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来源期刊

Clinical and Molecular Allergy Medicine-Immunology and Allergy

CiteScore

8.20

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Clinical and Molecular Allergy is an open access, peer-reviewed, online journal that publishes research on human allergic and immunodeficient disease (immune deficiency not related to HIV infection/AIDS). The scope of the journal encompasses all aspects of the clinical, genetic, molecular and inflammatory aspects of allergic-respiratory (Type 1 hypersensitivity) and non-AIDS immunodeficiency disorders. However, studies of allergic/hypersensitive aspects of HIV infection/AIDS or drug desensitization protocols in AIDS are acceptable. At the basic science level, this includes original work and reviews on the genetic and molecular mechanisms underlying the inflammatory response.