评估早期类风湿关节炎患者的脂肪因子谱(脂联素、抵抗素、脂素、血管素和瘦素)及其与疾病活动度的相关性

IF 1.4 Q3 RHEUMATOLOGY
Reumatologia Pub Date : 2022-01-01 Epub Date: 2022-07-13 DOI:10.5114/reum.2022.117839
Yany Magali Chamorro-Melo, Omar-Javier Calixto, Juan Manuel Bello-Gualtero, Wilson Bautista-Molano, Adriana Beltran-Ostos, Consuelo Romero-Sánchez
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引用次数: 5

摘要

简介:脂肪因子可能在类风湿关节炎的早期阶段发挥作用。本研究评估了脂肪因子在哥伦比亚早期类风湿关节炎患者中的表现及其与疾病活动度的关系。材料和方法:一项横断面研究评估了早期类风湿关节炎(eRA)患者血清脂肪因子水平(脂联素、抵抗素、脂素、vaspin和瘦素),评估了人口统计学和临床变量,以及与年龄和性别匹配的对照组。采用主成分分析(PCA)进行因子分析,并进行Spearman相关分析。同样,基于eRA与对照组之间的受试者工作特征(ROC)曲线和敏感性分析,提出了血清水平的截断点。结果:纳入eRA受试者51例;有41名女性。体重指数(BMI)为25.12±3.8。脂素、BMI和RAPID3之间存在统计学上显著的相关性。Vaspin和leptin与BMI相关。RAPID3接近缓解期患者的抵抗素水平较高(p = 0.041), DAS28 ESR缓解期患者的脂联素、vaspin和瘦素水平较低(p = 0.033、p = 0.012和p = 0.017)。以BMI和RAPID3为疾病活动度指数,对脂肪因子成分1中的脂素和瘦素进行主成分分析。此外,组分2在ESR和CRP之间有很强的相关性,与胆固醇水平和血管素呈负相关。为每个脂肪因子建立了截断点,从而确定瘦素水平大于0.58 ng/ml的最佳性能,灵敏度为76.5%,特异性为74.5%。结论:脂肪因子水平与eRA相关,尤其是与疾病活动性指标相关。抵抗素水平在活动指数接近缓解的患者中较高。此外,低活动指数患者的脂联素、vaspin和瘦素水平较低。RAPID3与adipsin相关。这是对先前发表的脂肪因子分析的补充。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity.

Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity.

Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity.

Introduction: Adipokines may play a role in the early stages of rheumatoid arthritis. This study evaluated the performance of adipokines in a Colombian population with early rheumatoid arthritis and its relationship with disease activity.

Material and methods: A cross-sectional study evaluated serum adipokine levels (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis (eRA), evaluating demographic and clinical variables, along with a control group matched by age and gender. A factorial analysis was performed using principal components analysis (PCA), and a Spearman correlation analysis was performed. Similarly, a cut-off point for serum levels is proposed based on the receiver operating characteristic (ROC) curve between eRA and controls and sensitivity analysis.

Results: Fifty-one eRA subjects were included; there were 41 women. The body mass index (BMI) was 25.12 ±3.8. A statistically significant correlation was identified between adipsin, BMI, and RAPID3. Vaspin and leptin were correlated with BMI. Resistin levels were higher in patients with RAPID3 near remission (p = 0.041), and adiponectin, vaspin, and leptin levels were lower in patients with DAS28 ESR in remission (p = 0.033, p = 0.012, and p = 0.017, respectively). Principal components analysis in component 1 adipokines as adipsin and leptin with BMI and RAPID3 as disease activity index are grouped. Moreover, component 2 had a strong relation between ESR and CRP with an inverse correlation with cholesterol levels and vaspin. A cut-off point was established for each adipokine, thus identifying the best performance for leptin levels greater than 0.58 ng/ml with a sensitivity of 76.5% and specificity of 74.5%.

Conclusions: Adipokine levels are relevant in eRA, especially with disease activity indexes. Resistin levels were higher in patients with an activity index near remission. Otherwise, adiponectin, vaspin, and leptin levels were lower in patients with low activity indexes. RAPID3 correlated with adipsin. It is complementary to the previously published analysis of adipokines.

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来源期刊
Reumatologia
Reumatologia Medicine-Rheumatology
CiteScore
2.70
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0.00%
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44
审稿时长
10 weeks
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