自闭症谱系障碍的小脑结构和功能。

Journal of psychiatry and brain science Pub Date : 2022-01-01 Epub Date: 2022-06-27 DOI:10.20900/jpbs.20220003
Bess F Bloomer, Jaime J Morales, Amanda R Bolbecker, Dae-Jin Kim, William P Hetrick
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引用次数: 1

摘要

自闭症谱系障碍(ASD)是一种异质性神经发育疾病,其特征是早发性重复行为、兴趣受限、感觉和运动困难以及社交障碍。来自神经影像学、病变和死后研究以及啮齿动物模型的证据表明,小脑参与了自闭症谱系障碍,并为该疾病的治疗干预指明了有希望的目标。本文通过对近期小脑结构和功能研究的整合和背景分析,阐明了对ASD中小脑机制的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cerebellar Structure and Function in Autism Spectrum Disorder.

Cerebellar Structure and Function in Autism Spectrum Disorder.

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by early-onset repetitive behaviors, restricted interests, sensory and motor difficulties, and impaired social interactions. Converging evidence from neuroimaging, lesion and postmortem studies, and rodent models suggests cerebellar involvement in ASD and points to promising targets for therapeutic interventions for the disorder. This review elucidates understanding of cerebellar mechanisms in ASD by integrating and contextualizing recent structural and functional cerebellar research.

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