聚光灯下的表观基因组肿瘤进化:单细胞方法的前景。

IF 0.7 4区生物学 Q4 BIOLOGY

Comptes Rendus Biologies Pub Date : 2022-05-11 DOI:10.5802/crbiol.75

Céline Vallot

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引用次数: 0

摘要

长期以来，癌症的进化被简化为一个遗传方程式。在单细胞方法的催化下，最新的技术和随后的概念进展，现在开始揭示长期以来被怀疑的表观基因组和转录组机制在癌症进化中所起的作用。在整合个体癌细胞随时间和空间的多模式测量方面面临着许多挑战，同时致力于更好的疾病管理和治疗靶点和生物标志物的发现。

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Epigenomic tumor evolution under the spotlight: the promises of single-cell approaches.

Cancer evolution was long-reduced to a genetic equation. The latest technological and subsequent conceptual advances, catalyzed by single-cell approaches, now begin to reveal the long-suspected part played by epigenomic and transcriptomic mechanisms in cancer evolution. Lie ahead numerous challenges to integrate multi-modal measurements of individual cancer cells over time and space, while aiming for better disease management and the discovery of therapeutic targets and biomarkers.

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来源期刊

Comptes Rendus Biologies 生物-生物学

CiteScore

2.40

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The Comptes rendus Biologies publish monthly communications dealing with all biological and medical research fields (biological modelling, development and reproduction biology, cell biology, biochemistry, neurosciences, immunology, pharmacology, ecology, etc.). Articles are preferably written in English. Articles in French with an abstract in English are accepted.