无绒病毒科和红多病毒科在人类中的神秘作用

IF 5.7 2区医学 Q1 VIROLOGY

Current opinion in virology Pub Date : 2022-08-01 DOI:10.1016/j.coviro.2022.101248

Louis J Taylor , Emma L Keeler , Frederic D Bushman , Ronald G Collman

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引用次数: 10

摘要

无球病毒科和红多病毒科是具有小的环状单链DNA基因组的病毒科，是人类病毒组的常见组成部分。尽管它们的基因组很小，只有不到5000个碱基，但它们却非常成功——在90%以上的成年人中，蛔虫病毒是定植的，而最近发现的红多囊病毒在某些人群中的流行率高达80%。蛔虫病毒存在于血液和许多器官中，而虹膜病毒主要存在于呼吸道中。尽管其发病率很高，但对其生物学或致病潜力知之甚少。在这篇综述中，我们讨论了棘球病毒和红粒病毒，并探讨了它们在人类健康和疾病中的神秘作用。

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The enigmatic roles of Anelloviridae and Redondoviridae in humans

Anelloviridae and Redondoviridae are virus families with small, circular, single-stranded DNA genomes that are common components of the human virome. Despite their small genome size of less than 5000 bases, they are remarkably successful — anelloviruses colonize over 90% of adult humans, while the recently discovered redondoviruses have been found at up to 80% prevalence in some populations. Anelloviruses are present in blood and many organs, while redondoviruses are found mainly in the ororespiratory tract. Despite their high prevalence, little is known about their biology or pathogenic potential. In this review, we discuss anelloviruses and redondoviruses and explore their enigmatic roles in human health and disease.

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来源期刊

Current opinion in virology VIROLOGY-

CiteScore

11.80

自引率

5.10%

发文量

审稿时长

83 days

期刊介绍： Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.