成人非囊性纤维化支气管扩张或复发性肺炎的正常IgG抗体缺乏:横断面研究。

IF 0.7 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Colombia Medica Pub Date : 2022-05-30 eCollection Date: 2022-04-01 DOI:10.25100/cm.v53i2.4832

Andres F Zea-Vera, Mario Alejandro Chacón, Beatriz Parra

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引用次数: 0

摘要

背景:先天性免疫缺陷，主要是IgG水平正常的抗体缺陷，在支气管扩张或复发性肺炎等肺部疾病的成人中未被发现。目的:检测成人非囊性纤维化支气管扩张或复发性肺炎患者的IgM、IgA、IgG2亚类缺陷和特异性抗体缺陷(抗肺炎球菌多糖抗体)。方法:横断面研究。在哥伦比亚卡利招募了非囊性纤维化支气管扩张或复发性肺炎的连续患者。测定抗肺炎球菌血清IgG、IgA、IgM、IgE、igg2亚类和IgG水平。结果:在纳入的110名参与者中，有11例(10%)患者血清IgG水平正常，但抗体缺乏。IgA缺乏症(3例)、IgM缺乏症(2例)和IgG2缺乏症(2例)是最常见的原发性免疫缺陷。IgG2+IgA缺乏症、共济失调性毛细血管扩张症、高ige综合征和特异性抗体缺乏(抗多糖)各1例。结论:IgG水平正常的抗体缺乏是成人非囊性纤维化、支气管扩张和复发性肺炎的重要病因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Antibody deficiencies with normal IgG in adults with Non-cystic fibrosis bronchiectasis or recurrent pneumonia: Cross-sectional study.

查看原文本刊更多论文

Antibody deficiencies with normal IgG in adults with Non-cystic fibrosis bronchiectasis or recurrent pneumonia: Cross-sectional study.

Abstract Background: Inborn errors of immunity, mainly Predominantly Antibody deficiencies with normal IgG levels are unrecognized in adults with lung diseases such as bronchiectasis or recurrent pneumonia. Objective: To determine IgM, IgA, IgG2 subclass deficiencies, and Specific antibody deficiency (anti-pneumococcal polysaccharide antibodies) in adults with non-cystic fibrosis bronchiectasis or recurrent pneumonia. Methods: Cross-sectional study. Consecutive patients with non-cystic fibrosis bronchiectasis or recurrent pneumonia were recruited in Cali, Colombia. IgG, IgA, IgM, and IgE, IgG2subclass and IgG anti-pneumococcal serum levels were measured. Results: Among the 110 participants enrolled, Antibody deficiencies with normal serum IgG levels were found in 11(10%) cases. IgA deficiency (3 cases), IgM deficiency (2 cases) and IgG2 deficiency (2 cases) were the most frequent primary immunodeficiencies. In addition, IgG2+IgA deficiency, Ataxia-telangiectasia, Hyper-IgE syndrome and Specific Antibody Deficiency(anti-polysaccharides) were found in one case each. Conclusions: Predominantly antibody deficiencies with normal IgG levels are an important etiology of non-cystic fibrosis bronchiectasis and recurrent pneumonia in adults.

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来源期刊

Colombia Medica MEDICINE, GENERAL & INTERNAL-

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Colombia Médica is an international peer-reviewed medical journal that will consider any original contribution that advances or illuminates medical science or practice, or that educates to the journal''s’ readers.The journal is owned by a non-profit organization, Universidad del Valle, and serves the scientific community strictly following the International Committee of Medical Journal Editors (ICMJE) and the World Association of Medical Editors (WAME) recommendations of policies on publication ethics policies for medical journals. Colombia Médica publishes original research articles, viewpoints and reviews in all areas of medical science and clinical practice. However, Colombia Médica gives the highest priority to papers on general and internal medicine, public health and primary health care.