[乙酰化，甲基化和泛素化的蛋白质在实验性缺血性中风小鼠:生物信息学分析]。

Q3 Biochemistry, Genetics and Molecular Biology

Biomeditsinskaya khimiya Pub Date : 2022-11-01 DOI:10.18097/PBMC20226805390

V S Skvortsov, Y O Ivanova, A I Voronina

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引用次数: 0

摘要

使用综合多组学方法在小鼠血液中分析获得的实验结果(加入代码PXD016538) (Simats et al. (2020) Molecular and Cellular Proteomics, 19(12)， 1921-1936)，以确定缺血性中风的潜在生物标志物。乙酰化、甲基化和泛素化被认为是翻译后修饰。对比假手术后小鼠脑缺血组织与脑卒中未损伤组织及对照组，分析缺血组织蛋白修饰水平变化的意义。在Mann-Whitney检验差异有统计学意义的水平上(p < 0.05)，发现2个蛋白(Q02248和Q8BL66);另外7种蛋白差异有统计学意义(p < 0.1)。在9种选定的蛋白质中，有7种与脑缺血有关，在文献中有报道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[Acetylation, methylation, and ubiquitination of proteins in experimental ischemic stroke in mice: a bioinformatics analysis].

The experimental results available in the ProteomeXchange database (accession code PXD016538) (Simats et al. (2020) Molecular and Cellular Proteomics, 19(12), 1921-1936) obtained using a comprehensive multi-omics approach were analyzed in mouse blood to identify potential biomarkers of ischemic stroke. Acetylation, methylation, and ubiquitination were considered as post-translational modifications. The analysis of the significance of changes in the level of protein modification was evaluated for ischemic tissue in comparison with tissue undamaged by stroke and control taken from mice after sham operation. At the level of statistically significant differences according to the Mann-Whitney test (p < 0.05), 2 proteins were found (Q02248 and Q8BL66); for additional 7 proteins, the differences were at the level of a statistical trend (p < 0.1). For 7 of 9 selected proteins there are reports in the literature, for their association with cerebral ischemia.

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来源期刊

Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).