{"title":"一些埃及植物提取物抗弓形虫活性的体外研究","authors":"Sara T. Elazab, Fadwa M. Arafa","doi":"10.1007/s11686-022-00633-2","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>Toxoplasmosis is a globally widespread parasitic disease which causes major health problems in human and animals. This research was conducted to assess the effect of some Egyptian herbal extracts against <i>Toxoplasma gondii</i> (<i>T. gondii)</i> tachyzoites in vitro.</p><h3>Methods</h3><p>The methanol extracts of <i>Withania somnifera, Cyper rotundus</i>, <i>Acacia nilotica</i><b>,</b> <i>Chrysanthemum cinerariae folium</i>, <i>Anethum graveolens</i>, <i>Raphanus sativus</i>, <i>Ceratonia siliqua</i>, <i>Elettaria cardamomum</i> and <i>Cuminum cyminum</i> were tested against <i>T. gondii</i> tachyzoites.</p><h3>Results</h3><p>Among the tested plants, the extracts from <i>Raphanus sativus, Cuminum cyminum,</i> and <i>Ceratonia siliqua</i> exhibited high <i>anti-Toxoplasma</i> activities at 50 µg/ml, relative to sulfadiazine. They showed low IC<sub>50</sub> values on <i>T. gondii</i> (7.92, 9.47 and 13.52 µg/ml, respectively) and high selectivity index values (100.79, 59.19, and 29.05, respectively). Scanning electron microscopy (SEM) findings indicated evident morphological changes in tachyzoites treated with these three herbal extracts.</p><h3>Conclusion</h3><p><i>Raphanus sativus</i>, <i>Ceratonia siliqua</i>, and <i>Cuminum cyminum</i> methanol extracts could be promising sources of new medicament for toxoplasmosis.</p></div>","PeriodicalId":6932,"journal":{"name":"Acta Parasitologica","volume":"67 4","pages":"1800 - 1806"},"PeriodicalIF":1.2000,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11686-022-00633-2.pdf","citationCount":"0","resultStr":"{\"title\":\"Anti-Toxoplasma Activities of Some Egyptian Plant Extracts: An In Vitro Study\",\"authors\":\"Sara T. Elazab, Fadwa M. Arafa\",\"doi\":\"10.1007/s11686-022-00633-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>Toxoplasmosis is a globally widespread parasitic disease which causes major health problems in human and animals. This research was conducted to assess the effect of some Egyptian herbal extracts against <i>Toxoplasma gondii</i> (<i>T. gondii)</i> tachyzoites in vitro.</p><h3>Methods</h3><p>The methanol extracts of <i>Withania somnifera, Cyper rotundus</i>, <i>Acacia nilotica</i><b>,</b> <i>Chrysanthemum cinerariae folium</i>, <i>Anethum graveolens</i>, <i>Raphanus sativus</i>, <i>Ceratonia siliqua</i>, <i>Elettaria cardamomum</i> and <i>Cuminum cyminum</i> were tested against <i>T. gondii</i> tachyzoites.</p><h3>Results</h3><p>Among the tested plants, the extracts from <i>Raphanus sativus, Cuminum cyminum,</i> and <i>Ceratonia siliqua</i> exhibited high <i>anti-Toxoplasma</i> activities at 50 µg/ml, relative to sulfadiazine. They showed low IC<sub>50</sub> values on <i>T. gondii</i> (7.92, 9.47 and 13.52 µg/ml, respectively) and high selectivity index values (100.79, 59.19, and 29.05, respectively). Scanning electron microscopy (SEM) findings indicated evident morphological changes in tachyzoites treated with these three herbal extracts.</p><h3>Conclusion</h3><p><i>Raphanus sativus</i>, <i>Ceratonia siliqua</i>, and <i>Cuminum cyminum</i> methanol extracts could be promising sources of new medicament for toxoplasmosis.</p></div>\",\"PeriodicalId\":6932,\"journal\":{\"name\":\"Acta Parasitologica\",\"volume\":\"67 4\",\"pages\":\"1800 - 1806\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2022-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s11686-022-00633-2.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Parasitologica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11686-022-00633-2\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PARASITOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Parasitologica","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s11686-022-00633-2","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PARASITOLOGY","Score":null,"Total":0}
Anti-Toxoplasma Activities of Some Egyptian Plant Extracts: An In Vitro Study
Purpose
Toxoplasmosis is a globally widespread parasitic disease which causes major health problems in human and animals. This research was conducted to assess the effect of some Egyptian herbal extracts against Toxoplasma gondii (T. gondii) tachyzoites in vitro.
Methods
The methanol extracts of Withania somnifera, Cyper rotundus, Acacia nilotica,Chrysanthemum cinerariae folium, Anethum graveolens, Raphanus sativus, Ceratonia siliqua, Elettaria cardamomum and Cuminum cyminum were tested against T. gondii tachyzoites.
Results
Among the tested plants, the extracts from Raphanus sativus, Cuminum cyminum, and Ceratonia siliqua exhibited high anti-Toxoplasma activities at 50 µg/ml, relative to sulfadiazine. They showed low IC50 values on T. gondii (7.92, 9.47 and 13.52 µg/ml, respectively) and high selectivity index values (100.79, 59.19, and 29.05, respectively). Scanning electron microscopy (SEM) findings indicated evident morphological changes in tachyzoites treated with these three herbal extracts.
Conclusion
Raphanus sativus, Ceratonia siliqua, and Cuminum cyminum methanol extracts could be promising sources of new medicament for toxoplasmosis.
期刊介绍：
Acta Parasitologica is an international journal covering the latest advances in the subject.
Acta Parasitologica publishes original papers on all aspects of parasitology and host-parasite relationships, including the latest discoveries in biochemical and molecular biology of parasites, their physiology, morphology, taxonomy and ecology, as well as original research papers on immunology, pathology, and epidemiology of parasitic diseases in the context of medical, veterinary and biological sciences. The journal also publishes short research notes, invited review articles, book reviews.
The journal was founded in 1953 as "Acta Parasitologica Polonica" by the Polish Parasitological Society and since 1954 has been published by W. Stefanski Institute of Parasitology of the Polish Academy of Sciences in Warsaw. Since 1992 in has appeared as Acta Parasitologica in four issues per year.
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