[利福平对长期饮酒大鼠戒酒期间大脑伏隔核toll样受体系统的影响]。

Q3 Biochemistry, Genetics and Molecular Biology
M I Airapetov, S O Eresko, D A Skabelkin, A R Iskalieva, A A Lebedev, E R Bychkov, P D Shabanov
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引用次数: 0

摘要

伏隔核(NAc)是大脑纹状体的腹侧部分;它是中边缘通路的一个重要组成部分,涉及奖励系统,介导各种形式的成瘾,特别是酒精成瘾的形成。神经影像学数据和体外研究表明,NAc中出现了明显的神经退行性过程,与长期饮酒有关,但介导这一过程的关键机制尚不清楚。近年来,研究者们的注意力主要集中在toll样受体(TLRs)系统的研究上,在长时间酒精暴露的情况下,TLRs在大脑皮层和海马中的活性明显增加,但该系统在其他脑结构中的作用还需要进一步研究。在这项研究中,我们已经证明,在大鼠酒精戒断期间,中等剂量的乙醇(2 g/kg)长期暴露于酒精(2个月)可促进NAc中Tlr4基因及其内源性配体Hmgb1的表达显著增加。注射利福平(100 mg/kg)降低了Hmgb1、Tlr4和促炎细胞因子基因(il - 1β、il - 6)的升高表达水平,而给药增加了抗炎细胞因子(il - 10、il - 11) mRNA的降低水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The effect of rifampicin on the system of Toll-like receptors in the nucleus accumbens of the brain of long-term alcoholized rats during alcohol withdrawal].

Nucleus accumbens (NAc) is the ventral part of the striatum of the brain; it is an important part of the mesolimbic pathway involved in the reward system that mediates the formation of various forms of addiction, in particular alcohol addiction. Neuroimaging data and in vitro studies indicate the development of a pronounced neurodegenerative process in the NAc, with long-term alcohol use, but the key mechanisms mediating this process remain unknown. In recent years, the attention of researchers has been focused on studying the system of Toll-like receptors (TLRs), the increased activity of which is clearly shown in the cerebral cortex and hippocampus during prolonged alcohol exposure, but there is a need to study the role of this system in other brain structures. In this study, we have shown that prolonged alcohol exposure (2 months) with moderate doses of ethanol (2 g/kg) promotes a pronounced increase in the expression of the Tlr4 gene and its endogenous ligand Hmgb1 in NAc during the period of alcohol withdrawal in rats. Injections of rifampicin (100 mg/kg) reduced the elevated expression level of Hmgb1, Tlr4, as well as pro-inflammatory cytokine genes (IL1β, IL6), while the administration of the drug increased the reduced level of mRNA of anti-inflammatory cytokines (IL10, IL11).

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来源期刊
Biomeditsinskaya khimiya
Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.30
自引率
0.00%
发文量
49
期刊介绍: The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).
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