通过高通量测序观察人类大脑皮层的进化创新

IF 2.7 4区医学 Q2 DEVELOPMENTAL BIOLOGY

Developmental Neurobiology Pub Date : 2022-06-28 DOI:10.1002/dneu.22893

Ikuo K. Suzuki

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引用次数: 0

摘要

人类在进化过程中获得了一个巨大的大脑皮层，其中包含了数量巨大、种类繁多的细胞。这种进化的独特性为我们的认知创新和人类特有的神经发育和精神疾病特征提供了神经基础。由于人类大脑很难在体内用通常应用于动物模型的实验方法进行研究，近年来测序技术的进步为人类大脑解剖和发育提供了不可或缺的观点。本文综述了近年来基于高通量DNA测序技术对成人大脑皮层的独特特征和发育过程的研究进展。

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Evolutionary innovations of human cerebral cortex viewed through the lens of high-throughput sequencing

Humans had acquired a tremendously enlarged cerebral cortex containing a huge quantity and variety of cells during evolution. Such evolutionary uniqueness offers a neural basis of our cognitive innovation and human‐specific features of neurodevelopmental and psychiatric disorders. Since human brain is hardly examined in vivo with experimental approaches commonly applied on animal models, the recent advancement of sequencing technologies offers an indispensable viewpoint of human brain anatomy and development. This review introduces the recent findings on the unique features in the adult and the characteristic developmental processes of the human cerebral cortex, based on high‐throughput DNA sequencing technologies.

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来源期刊

Developmental Neurobiology 生物-发育生物学

CiteScore

6.50

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Developmental Neurobiology (previously the Journal of Neurobiology ) publishes original research articles on development, regeneration, repair and plasticity of the nervous system and on the ontogeny of behavior. High quality contributions in these areas are solicited, with an emphasis on experimental as opposed to purely descriptive work. The Journal also will consider manuscripts reporting novel approaches and techniques for the study of the development of the nervous system as well as occasional special issues on topics of significant current interest. We welcome suggestions on possible topics from our readers.