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引用次数: 0
摘要
乳腺癌是全世界妇女中最具威胁性的恶性肿瘤之一;因此,研究人员在这一领域不断进行新的研究。然而,准确预测其预后和术后恢复仍然很困难。乳腺癌的严重程度因人而异,受若干健康因素影响;因此,未知的机制可能影响其进展。本文将从ghrelin的发现到目前的使用,对现有的乳腺癌文献进行分析,旨在为今后乳腺癌机制的研究和治疗方案的改进提供参考。通过直接或间接的证据,胃饥饿素的各个部分都与乳腺癌有关。胃饥饿素系统可能包括扩大乳腺癌治疗方法和预后指标的方向。因此,我们整理了几乎所有关于ghrelin系统与乳腺癌关系的研究,包括未酰化的ghrelin及其GHRL基因、ghrelin o -酰基转移酶、受体生长激素促分泌素受体、ghrelin的几种剪接变异体等,为今后的研究奠定基础。
Breast cancer is one of the most threatening malignant tumors in women worldwide; hence, investigators are continually performing novel research in this field. However, an accurate prediction of its prognosis and postoperative recovery remains difficult. The severity of breast cancer is patient-specific and affected by several health factors; thus, unknown mechanisms may affect its progression. This article analyzes existing literature on breast cancer, ranging from the discovery of ghrelin to its present use, and aims to provide a reference for future research into breast cancer mechanisms and treatment-plan improvement. Various parts of ghrelin have been associated with breast cancer by direct or indirect evidence. The ghrelin system may encompass the direction of expanding breast cancer treatment methods and prognostic indicators. Therefore, we compiled almost all studies on the relationship between the ghrelin system and breast cancer, including unacylated ghrelin, its GHRL gene, ghrelin O-acyltransferase, the receptor growth hormone secretagogue receptor, and several splice variants of ghrelin to lay the foundation for future research.
期刊介绍:
IJBM is an international, online only, peer-reviewed Journal, which publishes original research and critical reviews primarily focused on cancer biomarkers. IJBM targets advanced topics regarding the application of biomarkers in oncology and is dedicated to solid tumors in adult subjects. The clinical scenarios of interests are screening and early diagnosis of cancer, prognostic assessment, prediction of the response to and monitoring of treatment.