电针与褪黑素对实验性神经损伤大鼠神经再生影响的比较。

IF 0.9 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE
Yasemin Özkan, Mehmet Turgut, Yasemin Turan, Mehmet Dinçer Bilgin, Sinem Sari, Mustafa Yilmaz, Yiğit Uyanikgil, Mahmut Alp Kiliç, Derya Tanriöver, Zehra Seznur Kasar
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引用次数: 0

摘要

背景:研究促进周围神经损伤后神经再生的方法具有重要意义。电针是传统针灸与现代电疗相结合的一种新型治疗方法。褪黑素已被证明可以减少神经损伤。目的:比较电针与褪黑素对大鼠坐骨神经损伤的治疗作用。方法:将56只成年雄性Wistar Albino大鼠分为4组,每组14只:完整对照组(I组)、皮下生理盐水组(II组)、皮下褪黑激素组(III组)、电针组(IV组)。II组、III组、IV组采用单侧(右)坐骨神经损伤手术方式,术后立即开始生理盐水和褪黑激素治疗6周,术后2周电针治疗3周。功能和组织学评估作为结果测量。结果:坐骨神经损伤引起神经传导速度明显降低。电针治疗和褪黑素治疗均能显著提高神经传导速度。与生理盐水组相比,这些治疗组的坐骨功能恢复和组织再生都更快。然而,在两个治疗组之间没有观察到显著差异。结论:电针联合褪黑素治疗周围神经损伤是一种很有前景的治疗策略,可以在未来的研究中进行详细的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the Effects of Electroacupuncture and Melatonin on Nerve Regeneration in Experimentally Nerve-Damaged Rats.

Background: Development of methods to accelerate nerve regeneration in peripheral nerve damage is important. Electroacupuncture is a new therapeutic method that combines traditional acupuncture with modern electrotherapy. Melatonin has been shown to reduce nerve damage. Objectives: In this study, we aimed to determine and compare the therapeutic effects of electroacupuncture and melatonin on rat sciatic nerve injury.

Methods: A total of 56 adult male Wistar Albino rats were divided into four study groups with 14 animals in each group: intact control (group I), subcutaneous saline (group II), subcutaneous melatonin (group III), and electroacupuncture (group IV). Surgical procedure including unilateral (right) sciatic nerve injury was applied to groups II, III, and IV. Saline and melatonin started immediately after surgery for six weeks, while electroacupuncture was given two weeks after surgery for 3 weeks. Functional and histological assessments were used as outcome measurements.

Results: Sciatic nerve damage caused a significant decrease in nerve conduction velocity. Both electroacupuncture treatment and melatonin treatment significantly increased the nerve conduction velocity. Both sciatic functional recovery and histological regeneration were faster in these treatment groups compared to the saline. However, no significant difference was observed between the two treatment groups.

Conclusion: Electroacupuncture and melatonin are promising alternative treatment strategies for peripheral nerve damage and can be examined in detail in future studies.

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来源期刊
Journal of Acupuncture and Meridian Studies
Journal of Acupuncture and Meridian Studies INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
1.50
自引率
10.00%
发文量
35
审稿时长
12 weeks
期刊介绍: The Journal of Acupuncture and Meridian Studies is a quarterly, peer-reviewed journal featuring high-quality studies related to basic and clinical acupuncture and meridian research. It also includes new paradigm of integrative research, covering East–West and traditional–modern medicine. Manuscripts should fall into one of the categories: topical review, original research paper, brief ... click here for full Aims & Scope The Journal of Acupuncture and Meridian Studies is a quarterly, peer-reviewed journal featuring high-quality studies related to basic and clinical acupuncture and meridian research. It also includes new paradigm of integrative research, covering East–West and traditional–modern medicine.
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