成人囊性纤维化患者调节治疗前后鼻窦疾病的ct分级。

IF 2 4区 医学 Q4 Medicine
Journal of the Belgian Society of Radiology Pub Date : 2022-06-14 eCollection Date: 2022-01-01 DOI:10.5334/jbsr.2812
Corrado Tagliati, Stefano Pantano, Giuseppe Lanni, Davide Battista, Matteo Marcucci, Marco Fogante, Giulio Argalia, Enrico Paci, Gabriella Lucidi Pressanti, Mingliang Ying, Pietro Ripani
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引用次数: 4

摘要

目的:囊性纤维化跨膜传导调节剂(CFTR)治疗对呼吸功能、肺恶化和生活质量的影响已被充分证实。然而,CFTR调节剂治疗鼻窦疾病的效果还没有很好的报道。先前的一项研究报道,ivacaftor可改善G551D突变囊性纤维化(CF)患者的计算机断层扫描(CT)上鼻窦疾病的表现。本研究的目的是在更广泛的CF患者群体中使用CT评分来评估CFTR调节剂治疗窦性疾病的效果。材料和方法:48例成年CF患者在CFTR调节剂治疗前(干扰素、肿瘤因子、干扰素/肿瘤因子或电激器/肿瘤因子/干扰素)至少进行一次CT窦部检查,并在CFTR调节剂治疗开始一年后进行一次CT窦部检查。两位放射科医生一致评估了这些图像。采用Lund-Mackay评分(LM评分)和Sheikh-Lind CT窦性疾病严重程度评分系统(SL评分)。在CFTR调节剂治疗前和CFTR调节剂开始治疗一年后,对22项鼻窦结局测试(SNOT-22)问卷进行评估。结果:CFTR调整剂治疗后CT鼻窦检查LM、SL、SNOT-22平均评分低于CFTR调整剂治疗前CT鼻窦检查,差异有统计学意义(p < 0.001)。结论:随访期间CT影像学表现的变化与CFTR调节剂治疗开始一年后SNOT-22评分的改善密切相关,提示CT可能是CF患者接受CFTR调节剂治疗后随访中有用的辅助手段,可作为鼻窦疾病改善的客观指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Sinus Disease Grading on Computed Tomography Before and After Modulating Therapy in Adult Patients with Cystic Fibrosis.

Sinus Disease Grading on Computed Tomography Before and After Modulating Therapy in Adult Patients with Cystic Fibrosis.

Sinus Disease Grading on Computed Tomography Before and After Modulating Therapy in Adult Patients with Cystic Fibrosis.

Sinus Disease Grading on Computed Tomography Before and After Modulating Therapy in Adult Patients with Cystic Fibrosis.

Objectives: Cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy effects on respiratory function, pulmonary exacerbations and quality of life have been well documented. However, CFTR modulator therapy effects on sinus disease have not been so well reported. A previous study reported that ivacaftor improves appearance of sinus disease on Computed Tomography (CT) in cystic fibrosis (CF) patients with G551D mutation. The aim of this study was to evaluate the effect of CFTR modulator therapy in sinus disease using CT scores in a wider CF patient population.

Materials and methods: Forty-eight adult patients with CF underwent at least one CT sinus examination before CFTR modulator therapy (ivacaftor, lumacaftor, ivacaftor/lumacaftor or elexcaftor/tezacaftor/ivacaftor) and one CT sinus examination one year after CFTR modulator therapy initiation. Two radiologists assessed the images in consensus. The Lund-Mackay score (LM score) and the Sheikh-Lind CT sinus disease severity scoring system (SL score) were used. The 22-item SinoNasal Outcome Test (SNOT-22) questionnaire was evaluated before CFTR modulator therapy and one year after CFTR modulator therapy initiation.

Results: CT sinus examination after CFTR modulator therapy showed statistically significant lower mean LM, SL and SNOT-22 scores than CT sinus examination before CFTR modulator therapy (p < 0.001).

Conclusion: Evolution of imaging findings on CT during follow-up closely correlate with improved SNOT-22 score one year after CFTR modulator therapy initiation, indicating that CT may be a useful adjunct during follow-up of CF patients under this treatment as an objective measure of sinonasal disease improvement.

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来源期刊
Journal of the Belgian Society of Radiology
Journal of the Belgian Society of Radiology Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.60
自引率
5.00%
发文量
0
审稿时长
6-12 weeks
期刊介绍: The purpose of the Journal of the Belgian Society of Radiology is the publication of articles dealing with diagnostic and interventional radiology, related imaging techniques, allied sciences, and continuing education.
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