Ivan Cancarevic, Mahmoud Nassar, Ahmed Daoud, Hatem Ali, Nso Nso, Angelica Sanchez, Avish Parikh, Asma Ul Hosna, Bhavana Devanabanda, Nazakat Ahmed, Karim M Soliman
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This study looked at the outcomes and risk factors for adverse outcomes among patients on chronic hemodialysis for end-stage renal disease, a group of patients known to be particularly susceptible to infectious complications.</p><p><strong>Aim: </strong>To assess outcomes and risk factors for adverse outcomes of COVID-19 infection among patients on chronic hemodialysis.</p><p><strong>Methods: </strong>We searched PubMed/MEDLINE, EMBASE, <i>Reference Citation Analysis</i> (https://www.referencecitationanalysis.com/) and Web of Science databases for relevant terms and imported the results into the Covidence platform. From there, studies were assessed in two stages for relevance and quality, and data from studies that satisfied all the requirements were extracted into a spreadsheet. The data was then analyzed descriptively and statistically.</p><p><strong>Results: </strong>Of the 920 studies identified through the initial database search, only 17 were included in the final analysis. 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引用次数: 7
摘要
背景:2019冠状病毒病(COVID-19)是过去几年人们谈论最多的疾病。有明显合并症的患者发生不良后果的风险特别大。本研究观察了终末期肾病患者进行慢性血液透析的结局和不良结局的危险因素，这组患者已知特别容易发生感染性并发症。目的:评价慢性血液透析患者COVID-19感染不良结局的结局及危险因素。方法:在PubMed/MEDLINE、EMBASE、Reference Citation Analysis (https://www.referencecitationanalysis.com/)和Web of Science数据库中检索相关术语，并将结果导入covid平台。在此基础上，研究分为相关性和质量两个阶段进行评估，满足所有要求的研究数据被提取到电子表格中。然后对数据进行描述性和统计学分析。结果:通过初始数据库检索确定的920项研究中，只有17项被纳入最终分析。分析中包括的研究大多是在第一波期间进行的。我们发现COVID-19在血液透析患者中的发病率显著，在一些研究中超过10%。感染COVID-19的人最有可能住院，超过五分之一的人死于感染。重症监护病房住院率低于感染致死率。生化异常和呼吸困难通常与不良结果相关。结论:本系统综述证实慢性血液透析患者是COVID-19感染的高危人群，且有相当比例的患者在第一波感染。他们的预后总体上比一般人群差得多，需要尽一切努力减少他们的接触。
Mortality rate of COVID-19 infection in end stage kidney disease patients on maintenance hemodialysis: A systematic review and meta-analysis.
Background: Coronavirus disease 2019 (COVID-19) has been the most talked-about disease of the past few years. Patients with significant comorbidities have been at particular risk of adverse outcomes. This study looked at the outcomes and risk factors for adverse outcomes among patients on chronic hemodialysis for end-stage renal disease, a group of patients known to be particularly susceptible to infectious complications.
Aim: To assess outcomes and risk factors for adverse outcomes of COVID-19 infection among patients on chronic hemodialysis.
Methods: We searched PubMed/MEDLINE, EMBASE, Reference Citation Analysis (https://www.referencecitationanalysis.com/) and Web of Science databases for relevant terms and imported the results into the Covidence platform. From there, studies were assessed in two stages for relevance and quality, and data from studies that satisfied all the requirements were extracted into a spreadsheet. The data was then analyzed descriptively and statistically.
Results: Of the 920 studies identified through the initial database search, only 17 were included in the final analysis. The studies included in the analysis were mostly carried out during the first wave. We found that COVID-19 incidence among patients on hemodialysis was significant, over 10% in some studies. Those who developed COVID-19 infection were most likely going to be hospitalized, and over 1 in 5 died from the infection. Intensive care unit admission rate was lower than the infection lethality rate. Biochemical abnormalities and dyspnea were generally reported to be associated with adverse outcomes.
Conclusion: This systematic review confirms that patients on chronic hemodialysis are very high-risk individuals for COVID-19 infections, and a significant proportion was infected during the first wave. Their prognosis is overall much worse than in the general population, and every effort needs to be made to decrease their exposure.
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