Melis Cansu Comert, Sezen Yilmaz, Ayse Yildiz Tas, Afsun Sahin
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For each group, corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT), Goldmann-correlated intraocular pressure (IOPg) and corneal compensated intraocular pressure (IOPcc) parameters were measured by ORA.</p><p><strong>Results: </strong>The mean age was 38.8±11.6 years for the TED patients and 42.9±15.58 years for the control group. For TED patients and healthy volunteers, the mean levels of CRF, CH, and CCT were measured as follows: 10.43±2.04 vs 10.28±1.91mmHg, p=0.67; 10.18±1.81 vs 10.21±1.68 mmHg, p=0.90; 550.31±35.73 vs 545.23±37.91 µm, p=0.47, respectively. These values were not significant between groups, but they were significantly higher in females compared to males in TED patients [CRF;10.68 (IQR: 9.49-12.14) vs 8.96 (IQR: 8.04-9.92) mmHg, p=0.002, CH; 10.43 (IQR: 9.48-11.25) vs 8.58 (IQR: 7.90-9.95) mmHg, p=0.003 and CCT; 554.25 (IQR: 536.05-579.52) vs 527.40 (IQR: 492.25-545.90) μm, p=0.014]. CRF values were negatively correlated with NOSPECS score (r=-0.317, p=0.036) and significantly higher CRF was observed in mild patients compared to severe disease (11.43 (IQR: 10.14-12.87) vs 9.46 (IQR: 8.75-10.28) mmHg, p=0.008).</p><p><strong>Conclusion: </strong>We found a significant gender effect on corneal biomechanical parameters of TED patients. CRF, CH and CCT values were significantly higher in females compared to males with TED. The clinical severity score of TED showed negative correlation with CRF. CRF value might be a useful parameter in follow-up of TED patients in clinical practice.</p>","PeriodicalId":8740,"journal":{"name":"Beyoglu Eye Journal","volume":"7 3","pages":"193-198"},"PeriodicalIF":0.0000,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/27/BEJ-7-193.PMC9522990.pdf","citationCount":"0","resultStr":"{\"title\":\"The Effect of Thyroid Eye Disease on Corneal Biomechanical Properties.\",\"authors\":\"Melis Cansu Comert, Sezen Yilmaz, Ayse Yildiz Tas, Afsun Sahin\",\"doi\":\"10.14744/bej.2022.08941\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>The aim of this study was to identify corneal biomechanical parameters measured by ORA in patients with TED compared to the healthy group. The NOSPECS classification of patients is used to assess the relation between biomechanical changes and disease severity.</p><p><strong>Methods: </strong>We included 22 TED patients, diagnosed with TED for more than five years, and 43 healthy participants. The NOSPECS classification was assessed as mild (grade 1-3) and severe (grade 4-6) disease. For each group, corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT), Goldmann-correlated intraocular pressure (IOPg) and corneal compensated intraocular pressure (IOPcc) parameters were measured by ORA.</p><p><strong>Results: </strong>The mean age was 38.8±11.6 years for the TED patients and 42.9±15.58 years for the control group. For TED patients and healthy volunteers, the mean levels of CRF, CH, and CCT were measured as follows: 10.43±2.04 vs 10.28±1.91mmHg, p=0.67; 10.18±1.81 vs 10.21±1.68 mmHg, p=0.90; 550.31±35.73 vs 545.23±37.91 µm, p=0.47, respectively. These values were not significant between groups, but they were significantly higher in females compared to males in TED patients [CRF;10.68 (IQR: 9.49-12.14) vs 8.96 (IQR: 8.04-9.92) mmHg, p=0.002, CH; 10.43 (IQR: 9.48-11.25) vs 8.58 (IQR: 7.90-9.95) mmHg, p=0.003 and CCT; 554.25 (IQR: 536.05-579.52) vs 527.40 (IQR: 492.25-545.90) μm, p=0.014]. CRF values were negatively correlated with NOSPECS score (r=-0.317, p=0.036) and significantly higher CRF was observed in mild patients compared to severe disease (11.43 (IQR: 10.14-12.87) vs 9.46 (IQR: 8.75-10.28) mmHg, p=0.008).</p><p><strong>Conclusion: </strong>We found a significant gender effect on corneal biomechanical parameters of TED patients. CRF, CH and CCT values were significantly higher in females compared to males with TED. The clinical severity score of TED showed negative correlation with CRF. 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引用次数: 0
摘要
研究目的本研究的目的是通过ORA测量TED患者与健康组患者的角膜生物力学参数。采用 NOSPECS 患者分类法评估生物力学变化与疾病严重程度之间的关系：我们纳入了 22 名确诊 TED 超过 5 年的 TED 患者和 43 名健康参与者。根据 NOSPECS 分级，将患者分为轻度（1-3 级）和重度（4-6 级）两组。ORA 对每组患者的角膜滞后（CH）、角膜阻力因子（CRF）、角膜中央厚度（CCT）、戈德曼相关眼压（IOPg）和角膜代偿眼压（IOPcc）参数进行了测量：TED患者的平均年龄为（38.8±11.6）岁，对照组为（42.9±15.58）岁。TED患者和健康志愿者的CRF、CH和CCT的平均水平分别为（10.43±2.04）和（42.9±15.58）：分别为 10.43±2.04 vs 10.28±1.91mmHg，P=0.67；10.18±1.81 vs 10.21±1.68mmHg，P=0.90；550.31±35.73 vs 545.23±37.91µm，P=0.47。这些数值在组间无显著差异，但在 TED 患者中，女性明显高于男性 [CRF;10.68 (IQR: 9.49-12.14) vs 8.96 (IQR: 8. 04-9.92) mmHg]。CRF：10.68（IQR：9.49-12.14） vs 8.96（IQR：8.04-9.92）mmHg，p=0.002；CH：10.43（IQR：9.48-11.25） vs 8.58（IQR：7.90-9.95）mmHg，p=0.003；CCT：554.25（IQR：536.05-579.52） vs 527.40（IQR：492.25-545.90）μm，p=0.014]。CRF值与NOSPECS评分呈负相关（r=-0.317，p=0.036），轻度患者的CRF明显高于重度患者（11.43（IQR：10.14-12.87） vs 9.46（IQR：8.75-10.28）mmHg，p=0.008）：我们发现性别对TED患者的角膜生物力学参数有明显影响。女性 TED 患者的 CRF、CH 和 CCT 值明显高于男性。TED 的临床严重程度评分与 CRF 呈负相关。在临床实践中，CRF值可能是随访TED患者的有用参数。
The Effect of Thyroid Eye Disease on Corneal Biomechanical Properties.
Objectives: The aim of this study was to identify corneal biomechanical parameters measured by ORA in patients with TED compared to the healthy group. The NOSPECS classification of patients is used to assess the relation between biomechanical changes and disease severity.
Methods: We included 22 TED patients, diagnosed with TED for more than five years, and 43 healthy participants. The NOSPECS classification was assessed as mild (grade 1-3) and severe (grade 4-6) disease. For each group, corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT), Goldmann-correlated intraocular pressure (IOPg) and corneal compensated intraocular pressure (IOPcc) parameters were measured by ORA.
Results: The mean age was 38.8±11.6 years for the TED patients and 42.9±15.58 years for the control group. For TED patients and healthy volunteers, the mean levels of CRF, CH, and CCT were measured as follows: 10.43±2.04 vs 10.28±1.91mmHg, p=0.67; 10.18±1.81 vs 10.21±1.68 mmHg, p=0.90; 550.31±35.73 vs 545.23±37.91 µm, p=0.47, respectively. These values were not significant between groups, but they were significantly higher in females compared to males in TED patients [CRF;10.68 (IQR: 9.49-12.14) vs 8.96 (IQR: 8.04-9.92) mmHg, p=0.002, CH; 10.43 (IQR: 9.48-11.25) vs 8.58 (IQR: 7.90-9.95) mmHg, p=0.003 and CCT; 554.25 (IQR: 536.05-579.52) vs 527.40 (IQR: 492.25-545.90) μm, p=0.014]. CRF values were negatively correlated with NOSPECS score (r=-0.317, p=0.036) and significantly higher CRF was observed in mild patients compared to severe disease (11.43 (IQR: 10.14-12.87) vs 9.46 (IQR: 8.75-10.28) mmHg, p=0.008).
Conclusion: We found a significant gender effect on corneal biomechanical parameters of TED patients. CRF, CH and CCT values were significantly higher in females compared to males with TED. The clinical severity score of TED showed negative correlation with CRF. CRF value might be a useful parameter in follow-up of TED patients in clinical practice.
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