{"title":"慢性血液透析患者Copeptin与容量状态的相关性研究。","authors":"Negar Sheikh Davoodi, Farzanehsadat Minoo","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Currently There is no noninvasive chemical biomarker, available for evaluating volume status, in individuals with endstage kidney disease (ESKD). This study aimed to determine the relationship between copeptin level and volume status in hemodialysis patients.</p><p><strong>Methods: </strong>This clinical trial enrolled 84 patients with ESKD (Mean age ± SD: 54.31 ± 15.47) on maintenance hemodialysis (3-times weekly, 4h /session). Plasma levels of Hb, copeptin, HCT, Na, and BUN, patients' weight, systolic and diastolic blood pressure and mean arterial pressure were measured, before and after hemodialysis. Age, sex, etiology of kidney failure, and duration of dialysis were also recorded., and the correlation between copeptin level and all variables was evaluated.</p><p><strong>Results: </strong>There was a significant positive correlation between copeptin level and Hb (r = 0.313, P < .05), and HCT (r = 0.25, P < .05), while a negative association was found between copeptin level and Na (r = -0.051, P > .05) and IDWG (r = -0.05, P > .05). Although copeptin concentration was higher in females before (929.23 pmol/L) and after dialysis (783.3 pmol/L) than male patients (657.05 and 697.45 pmol/L), the mean copeptin changes was higher in male (205 pmol/L) than female (197 pmol/L) (P > .05). The level of copeptin decreased (P > .05) but the level of Hb (P < .05), HCT (P < .05), and Na (P > .05) were increased after dialysis compared to pre-dialysis period.</p><p><strong>Conclusions: </strong>Copeptin could be used as a surrogate marker for the diagnosis of volume status in hemodialysis patients. DOI: 10.52547/ijkd.7119.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":"16 5","pages":"298-303"},"PeriodicalIF":0.8000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Correlation Between Copeptin and Volume Status in Chronic Hemodialysis Patients.\",\"authors\":\"Negar Sheikh Davoodi, Farzanehsadat Minoo\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Currently There is no noninvasive chemical biomarker, available for evaluating volume status, in individuals with endstage kidney disease (ESKD). This study aimed to determine the relationship between copeptin level and volume status in hemodialysis patients.</p><p><strong>Methods: </strong>This clinical trial enrolled 84 patients with ESKD (Mean age ± SD: 54.31 ± 15.47) on maintenance hemodialysis (3-times weekly, 4h /session). Plasma levels of Hb, copeptin, HCT, Na, and BUN, patients' weight, systolic and diastolic blood pressure and mean arterial pressure were measured, before and after hemodialysis. Age, sex, etiology of kidney failure, and duration of dialysis were also recorded., and the correlation between copeptin level and all variables was evaluated.</p><p><strong>Results: </strong>There was a significant positive correlation between copeptin level and Hb (r = 0.313, P < .05), and HCT (r = 0.25, P < .05), while a negative association was found between copeptin level and Na (r = -0.051, P > .05) and IDWG (r = -0.05, P > .05). Although copeptin concentration was higher in females before (929.23 pmol/L) and after dialysis (783.3 pmol/L) than male patients (657.05 and 697.45 pmol/L), the mean copeptin changes was higher in male (205 pmol/L) than female (197 pmol/L) (P > .05). The level of copeptin decreased (P > .05) but the level of Hb (P < .05), HCT (P < .05), and Na (P > .05) were increased after dialysis compared to pre-dialysis period.</p><p><strong>Conclusions: </strong>Copeptin could be used as a surrogate marker for the diagnosis of volume status in hemodialysis patients. DOI: 10.52547/ijkd.7119.</p>\",\"PeriodicalId\":14610,\"journal\":{\"name\":\"Iranian journal of kidney diseases\",\"volume\":\"16 5\",\"pages\":\"298-303\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian journal of kidney diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian journal of kidney diseases","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
The Correlation Between Copeptin and Volume Status in Chronic Hemodialysis Patients.
Introduction: Currently There is no noninvasive chemical biomarker, available for evaluating volume status, in individuals with endstage kidney disease (ESKD). This study aimed to determine the relationship between copeptin level and volume status in hemodialysis patients.
Methods: This clinical trial enrolled 84 patients with ESKD (Mean age ± SD: 54.31 ± 15.47) on maintenance hemodialysis (3-times weekly, 4h /session). Plasma levels of Hb, copeptin, HCT, Na, and BUN, patients' weight, systolic and diastolic blood pressure and mean arterial pressure were measured, before and after hemodialysis. Age, sex, etiology of kidney failure, and duration of dialysis were also recorded., and the correlation between copeptin level and all variables was evaluated.
Results: There was a significant positive correlation between copeptin level and Hb (r = 0.313, P < .05), and HCT (r = 0.25, P < .05), while a negative association was found between copeptin level and Na (r = -0.051, P > .05) and IDWG (r = -0.05, P > .05). Although copeptin concentration was higher in females before (929.23 pmol/L) and after dialysis (783.3 pmol/L) than male patients (657.05 and 697.45 pmol/L), the mean copeptin changes was higher in male (205 pmol/L) than female (197 pmol/L) (P > .05). The level of copeptin decreased (P > .05) but the level of Hb (P < .05), HCT (P < .05), and Na (P > .05) were increased after dialysis compared to pre-dialysis period.
Conclusions: Copeptin could be used as a surrogate marker for the diagnosis of volume status in hemodialysis patients. DOI: 10.52547/ijkd.7119.
期刊介绍：
The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.
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