膳食脂肪酸在骨髓和外周血间中性粒细胞运输中的新证据

IF 4.1 Q2 FOOD SCIENCE & TECHNOLOGY
Almudena Ortega-Gomez , Sergio Lopez , Lourdes M. Varela , Sara Jaramillo , Francisco J.G. Muriana , Rocio Abia
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引用次数: 1

摘要

小鼠长期摄入高脂肪饮食已被证实会影响骨髓中中性粒细胞等免疫细胞的产生和运输,其失调可能导致多种疾病。然而,目前还没有研究证实短期高脂肪饮食可以在空腹和餐后对骨髓中性粒细胞释放的早期调节,以应对高脂肪饮食的挑战,并且膳食脂肪中的主要脂肪酸类型可能在这两种情况下都发挥作用。基于这些前提,我们旨在确定不同脂肪[富含饱和脂肪酸(SFAs)的黄油,富含单不饱和脂肪酸(MUFAs)的橄榄油,以及补充二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)的橄榄油]对小鼠骨髓到血液中性粒细胞导航的影响。我们对细胞模型进行了分析,以了解机制,并对健康志愿者的餐后血液样本进行了分析,以用于翻译目的。结果显示,日粮中添加sfa可促进中性粒细胞通过CXCL2-CXCR2轴从骨髓向血液的转运。饮食中的SFAs,而不是MUFAs或EPA和DHA,也与中性粒细胞凋亡和骨髓炎症增加有关。在其他健康人群中也观察到类似的膳食脂肪酸诱导的餐后中性粒细胞增多。因此,在高脂肪饮食过程中,即使在摄入高脂肪膳食后,膳食MUFAs也可能在早期保持骨髓健康和骨髓中性粒细胞的适当迁移。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood

New evidence for dietary fatty acids in the neutrophil traffic between the bone marrow and the peripheral blood

Chronic administration of a high-fat diet in mice has been established to influence the generation and trafficking of immune cells such as neutrophils in the bone marrow, the dysregulation of which may contribute to a wide range of diseases. However, no studies have tested the hypothesis that a short-term, high-fat diet could early modulate the neutrophil release from bone marrow at fasting and at postprandial in response to a high-fat meal challenge, and that the predominant type of fatty acids in dietary fats could play a role in both context conditions. Based on these premises, we aimed to establish the effects of different fats [butter, enriched in saturated fatty acids (SFAs), olive oil, enriched in monounsaturated fatty acids (MUFAs), and olive oil supplemented with eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids] on neutrophil navigation from bone marrow to blood in mice. The analysis of cellular models for mechanistic understanding and of postprandial blood samples from healthy volunteers for translational purposes was assessed. The results revealed a powerful effect of dietary SFAs in promotion the neutrophil traffic from bone marrow to blood via the CXCL2-CXCR2 axis. Dietary SFAs, but not MUFAs or EPA and DHA, were also associated with increased neutrophil apoptosis and bone marrow inflammation. Similar dietary fatty-acid-induced postprandial neutrophilia was observed in otherwise healthy humans. Therefore, dietary MUFAs might preserve bone marrow health and proper migration of bone marrow neutrophils early in the course of high-fat diets even after the intake of high-fat meals.

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来源期刊
Food Chemistry Molecular Sciences
Food Chemistry Molecular Sciences Agricultural and Biological Sciences-Food Science
CiteScore
6.00
自引率
0.00%
发文量
83
审稿时长
82 days
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