嗅裂息肉的嗅神经上皮:它们对鼻内镜手术后的嗅觉结果有影响吗?

IF 0.7 Q4 OTORHINOLARYNGOLOGY
Turkish Archives of Otorhinolaryngology Pub Date : 2022-06-01 Epub Date: 2022-08-31 DOI:10.4274/tao.2022.2022-4-5
Cengiz Özcan, Onur İsmi, Feyzi Meşe, İclal Gürses, Yusuf Vayisoğlu, Kemal Görür
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引用次数: 2

摘要

目的:嗅觉结构的存在对嗅觉裂息肉(OCPs)手术切除后嗅觉功能的影响尚不清楚。在这项研究中,我们旨在评估嗅觉结构在ocp中的存在,并将这些发现与内窥镜鼻窦手术(ESS)后的嗅觉结果联系起来。方法:27例OCP患者术前接受局部和全身类固醇治疗和ESS治疗。对中金属息肉(MMPs)和OCPs的活检组织进行嗅觉标记蛋白(OMP)的免疫组织化学分析。嗅觉测试应用于基线、类固醇治疗(AST)后和ESS后的患者。结果:与MMPs相比,OCPs表现出更普遍和强烈的OMP染色(p=0.008),但OMP染色评分与任何嗅觉评分之间均无相关性(p>0.05)。结论:在鼻息肉患者中,OCPs比MMPs含有更多的嗅神经上皮。然而,这一发现的外科重要性是有争议的,因为在我们的研究中,切除这些息肉并没有降低术后的嗅觉功能。术前接受类固醇治疗的鼻息肉患者必须被告知,ESS对嗅觉的成功取决于类固醇治疗的反应,ESS AST可能不会对嗅觉功能产生额外的有利影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Olfactory Neuroepithelium in Olfactory Cleft Polyps: Do They Have Any Effect on Olfaction Results After Endoscopic Sinus Surgery?

Olfactory Neuroepithelium in Olfactory Cleft Polyps: Do They Have Any Effect on Olfaction Results After Endoscopic Sinus Surgery?

Olfactory Neuroepithelium in Olfactory Cleft Polyps: Do They Have Any Effect on Olfaction Results After Endoscopic Sinus Surgery?

Olfactory Neuroepithelium in Olfactory Cleft Polyps: Do They Have Any Effect on Olfaction Results After Endoscopic Sinus Surgery?

Objective: How the presence of olfactory structures in olfactory cleft polyps (OCPs) affect olfaction function outcomes after surgical removal has not yet been investigated. In this study we aimed to assess the presence of olfactory structures in OCPs and correlate these findings with olfactory outcomes after endoscopic sinus surgery (ESS).

Methods: Twenty seven patients with OCP underwent preoperative topical and systemic steroid treatment and ESS. Biopsies from the middle meatal polyps (MMPs) and OCPs were immunohistochemically analyzed for olfactory marker protein (OMP). The smell diskettes olfaction test was applied to patients at baseline, after steroid treatment (AST) and after ESS.

Results: OCPs exhibited OMP staining more commonly and intensely compared to MMPs (p=0.008), however, there were no correlations between OMP staining scores and any of the olfaction scores (p>0.05). Steroid treatment increased smell function significantly (p<0.001), however, there were no significant differences between AST and after ESS smell scores (p=0.17). There were significant correlations between smell gains AST and final smell gains after ESS (r=0.665, p<0.001).

Conclusion: OCPs contain olfactory neuroepithelium more commonly and intensely than MMPs in nasal polyp patients. However, surgical importance of this finding is controversial because removal of these polyps did not decrease smell function postoperatively in our study. Nasal polyp patients who will take steroid treatment pre-operatively must be informed that the success of ESS on olfaction depends on the response of the steroid treatment and ESS AST might not have additional favorable effect on smell function.

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