甘油-3-磷酸酰基转移酶与代谢综合征:最新进展和未来展望。

IF 4.5 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Expert Reviews in Molecular Medicine Pub Date : 2022-09-05 DOI:10.1017/erm.2022.23

Yinqiong Huang, Keyue Hu, Shu Lin, Xiahong Lin

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引用次数: 2

摘要

甘油三酯-3-磷酸酰基转移酶(GPATs)是合成三酰甘油(TAG)第一步的关键酶。在哺乳动物中，gpat有四种同种异构体。GPAT1和GPAT2定位于线粒体外膜，而GPAT3和GPAT4定位于内质网。先前的研究强调GPAT在代谢综合征(如肝脂肪变性、肥胖和胰岛素抵抗)的发展中起着关键作用。在这篇综述中，我们将批判性地评估GPATs亚型在代谢综合征中的调节作用。此外，我们还讨论了神经代谢性疾病的临床干预策略的观点。

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Glycerol-3-phosphate acyltransferases and metabolic syndrome: recent advances and future perspectives.

Triglycerol-3-phosphate acyltransferases (GPATs) are the key enzymes in the first step of the synthesis of triacylglycerol (TAG). In mammals, there are four isoforms of GPATs. GPAT1 and GPAT2 are localised in the outer mitochondrial membrane, while GPAT3 and GPAT4 are localised in the endoplasmic reticulum. Previous research has emphasised that GPAT plays a critical effect on the development of metabolic syndromes, such as liver steatosis, obesity, and insulin resistance. In this review, we will critically evaluate the regulatory effects of GPATs isoforms in metabolic syndrome. In addition, we also discuss perspectives on clinical intervention strategies for the neurometabolic disease.

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来源期刊

Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

7.40

自引率

1.60%

发文量

期刊介绍： Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.