黑荆芥提取物对应激大鼠心肌磷脂组成的影响。

Q3 Pharmacology, Toxicology and Pharmaceutics

Ceska a Slovenska Farmacie Pub Date : 2022-01-01

Volodymyr Shvets, Hanna Maslak, Vadim Davydov, Halyna Berest, Inna Nosulenko

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引用次数: 0

摘要

本研究以Wistar系80只雄性大鼠为实验对象。实验动物分为两个年龄组:成人(10-12个月)和老年(22-25个月)。所获得的数据表明，成年和老年大鼠的固定应激的发展伴随着心肌磷脂组成变化的特征性复合物的形成。在固定前60分钟，以0.2 g/kg的剂量腹腔注射苦莓提取物(Aronia melanocarpa)对老年动物心肌磷脂组成的应激调节有限。由此可见，黑桫椤提取物增强了大鼠心肌对应激损伤的抵抗能力。

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The effect of Aronia melanocarpa extract on the phospholipid composition of the rat myocardium during stress.

The research was performed on 80 male rats of the Wistar line. Animals of two age groups were used: adults (10-12 months) and old (22-25 months). The obtained data show that the development of immobilization stress in adult and aged rats are accompanied by the formation of a characteristic complex of changes in the phospholipid composition of the myocardium. Intraperitoneal injection of the chokeberry extract (Aronia melanocarpa) at a dose of 0.2 g/kg 60 minutes before the immobilization has limited stress modulation of myocardial phospholipid composition in aged animals. Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.

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来源期刊

Ceska a Slovenska Farmacie Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.90

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0.00%

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期刊介绍： Přehledový článek je zaměřen zejména na metody přípravy, charakterizaci mikročástic a dále na charakteristiku a příklady jejich možného využití ve farmakoterapii. Mikročástice jako...