妊娠并发高血压疾病患者血液和尿液中 miR-101 水平的诊断价值。

IF 1.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2022-09-01 DOI:10.1080/10641963.2022.2110258

Yushan Li, Yuanyuan Wei, Jiong Shao

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引用次数: 0

摘要

研究目的本研究探讨了 miR-101 在妊娠期高血压并发症（HDCP）中的临床意义：方法：纳入妊娠高血压（GH）/轻度子痫前期（mPE）/重度子痫前期（sPE）孕妇。测量miR-101水平。评估了miR-101与可溶性类酪氨酸激酶-1（sFlt-1）之间的相关性、miR-101的预测价值以及影响HDCP分级的因素：血清 miR-101 下调，并与 sFlt-1 呈负相关。miR-101 是 HDCP 的独立危险因素，并随 HDCP 严重程度而降低。在区分 GH 和 mPE 以及 mPE 和 sPE 时，miR-101 的曲线下面积分别为 0.7764 和 0.8529：结论：血清 miR-101 水平可能是分级 HDCP 的生物标志物。

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Diagnostic value of miR-101 levels in blood and urine of patients with hypertensive disorder complicating pregnancy.

Objectives: This study explored the miR-101 clinical significance in hypertensive disorder complicating pregnancy (HDCP).

Methods: Pregnant women with gestational hypertension (GH)/mild preeclampsia (mPE)/severe preeclampsia (sPE) were included. The miR-101 levels were measured. Correlation between miR-101 and soluble fmslike tyrosine kinase-1 (sFlt-1), miR-101 predictive value, and factors influencing HDCP grade were evaluated.

Results: Serum miR-101 was down-regulated and negatively correlated with sFlt-1. miR-101 was an independent risk factor for HDCP and decreased with HDCP severity. The area under the curve of miR-101 in differentiating GH from mPE and mPE from sPE was 0.7764 and 0.8529.

Conclusion: Serum miR-101 level may be a biomarker for grading HDCP.

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.