真核生物DNA复制的起始。

IF 12.1 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Annual review of biochemistry Pub Date : 2022-06-21 Epub Date: 2022-03-23 DOI:10.1146/annurev-biochem-072321-110228

Alessandro Costa, John F X Diffley

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引用次数: 35

摘要

真核细胞中的DNA复制是从大量称为复制起点的位点开始的。必须严格控制从这些起点开始的复制，以确保整个基因组在每个细胞周期中精确复制。这是通过调节复制的前两个步骤来完成的:装载和激活复制DNA解旋酶。在这里，我们从遗传、生化和结构的角度描述了这两种反应的机制和调控，重点介绍了最近利用出芽酵母蛋白质的进展。

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The Initiation of Eukaryotic DNA Replication.

DNA replication in eukaryotic cells initiates from large numbers of sites called replication origins. Initiation of replication from these origins must be tightly controlled to ensure the entire genome is precisely duplicated in each cell cycle. This is accomplished through the regulation of the first two steps in replication: loading and activation of the replicative DNA helicase. Here we describe what is known about the mechanism and regulation of these two reactions from a genetic, biochemical, and structural perspective, focusing on recent progress using proteins from budding yeast.

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来源期刊

Annual review of biochemistry 生物-生化与分子生物学

CiteScore

33.90

自引率

0.00%

发文量

期刊介绍： The Annual Review of Biochemistry, in publication since 1932, sets the standard for review articles in biological chemistry and molecular biology. Since its inception, these volumes have served as an indispensable resource for both the practicing biochemist and students of biochemistry.