冠状病毒与人体内分泌系统:新数据(文献综述)。

Q4 Health Professions
S V Bulgakova, E V Treneva, N O Zakharova
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引用次数: 0

摘要

2019年12月,中国首次报道了一种新的危险呼吸道疾病COVID-19,病原体sars -冠状病毒2 (SARS-CoV-2),属于β冠状病毒属,除SARS-CoV-2外,还包括SARS-CoV-1和MERS-CoV。SARS-CoV-2的基因组几乎与SARS-CoV-1相似80%,与MERS-CoV相似50%。SARS-CoV-1和SARS-CoV-2的感染机制也相似,都是通过病毒与2型血管紧张素转换酶蛋白(ACE2)结合而发生的,ACE2在人体中广泛存在,主要表达于内分泌组织。因此,SARS-CoV-1和SARS-CoV-2会影响内分泌系统的器官,造成损害和激素变化,从而影响COVID-19病程的预后。本文献综述旨在分析SARS-CoV-1和SARS-CoV-2感染期间内分泌系统器官的变化,以及激素对SARS-CoV-2易感性的潜在影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Beta coronaviruses and human endocrine system: new data (review of literature).

A new dangerous respiratory disease COVID-19 was first reported in China in December 2019, the pathogen SARS-Coronavirus 2 (SARS-CoV-2), belonging to the beta coronavirus genus, which, in addition to SARS-CoV-2, includes SARS-CoV-1 and MERS-CoV. The genome of SARS-CoV-2 is almost 80% similar to SARS-CoV-1 and 50% to MERS-CoV. The mechanisms of infection of SARS-CoV-1 and SARS-CoV-2 are also similar and occur through the binding of the virus to the type 2 angiotensin-converting enzyme protein (ACE2), which is widely represented in the human body with predominant expression in endocrine tissues. In this connection, SARS-CoV-1 and SARS-CoV-2 affect the organs of the endocrine system, causing damage and hormonal changes that affect the prognosis of the course of COVID-19. This literature review is devoted to the analysis of changes in the organs of the endocrine system that occur during infection with SARS-CoV-1 and SARS-CoV-2, as well as the potential effect of hormones on susceptibility to SARS-CoV-2.

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来源期刊
Klinichescheskaya Laboratornaya Diagnostika
Klinichescheskaya Laboratornaya Diagnostika Health Professions-Medical Laboratory Technology
CiteScore
0.90
自引率
0.00%
发文量
110
期刊介绍: The journal deals with theoretical and practical problems of clinical laboratory diagnosis, publishes editorial articles, reviews of literature, original articles, short reports, discussions, book reviews, current events, materials which may assist the practitioners, methods of laboratory investigations used in medicine, materials on the results of practical application of new methods of investigation in the following fields of clinical laboratory diagnosis: hematology, cytology, coagulation, biochemistry, immunology.
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