转运体是如何结合溶质运动的?

Q3 Biochemistry, Genetics and Molecular Biology

Molecular Membrane Biology Pub Date : 2013-11-01 DOI:10.3109/09687688.2013.842658

Gary Rudnick

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引用次数: 16

摘要

高分辨率转运蛋白原子结构的可用性为了解其作用机制提供了前所未有的机会。构象变化的细节可以从这些结构中推断出来，特别是当有多个构象可用时。然而，转运体耦合一种溶质与另一种溶质运动的独特能力需要比晶体结构提供的信息更多的信息。这篇简短的评论讨论了最近的生物化学和生物物理学研究是如何开始揭示溶质耦合是如何实现的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

How do transporters couple solute movements?

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How do transporters couple solute movements?

Abstract The availability of high-resolution atomic structures for transport proteins provides unprecedented opportunities for understanding their mechanism of action. The details of conformational change can be deduced from these structures, especially when multiple conformations are available. However, the singular ability of transporters to couple the movement of one solute to that of another requires even more information than what is supplied by a crystal structure. This short commentary discusses how recent biochemical and biophysical studies are beginning to reveal how solute coupling is achieved.

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来源期刊

Molecular Membrane Biology 生物-生化与分子生物学

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Cessation. Molecular Membrane Biology provides a forum for high quality research that serves to advance knowledge in molecular aspects of biological membrane structure and function. The journal welcomes submissions of original research papers and reviews in the following areas: • Membrane receptors and signalling • Membrane transporters, pores and channels • Synthesis and structure of membrane proteins • Membrane translocation and targeting • Lipid organisation and asymmetry • Model membranes • Membrane trafficking • Cytoskeletal and extracellular membrane interactions • Cell adhesion and intercellular interactions • Molecular dynamics and molecular modelling of membranes. • Antimicrobial peptides.