SARS-CoV-2感染中的自然杀伤细胞耗竭

IF 2.8 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Innate Immunity Pub Date : 2022-08-01 Epub Date: 2022-06-22 DOI:10.1177/17534259221077750
Janet Gallardo-Zapata, Carmen Maldonado-Bernal
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引用次数: 4

摘要

2019年底,中国武汉爆发了一场严重的呼吸道疾病,未知肺炎病例有所增加。2020年1月,一种名为SARS-CoV-2的新型冠状病毒被确定为病因。该病毒主要通过呼吸道传播,在重症患者中观察到淋巴细胞减少和细胞因子风暴。这表明,在由该病毒引起的严重疾病期间,存在免疫失调的伴随事件。自然杀伤(NK)细胞是先天免疫应答者,对病毒脱落和免疫调节至关重要。尽管NK细胞在病毒感染中很重要,但它在对抗SARS-CoV-2中的作用尚未被破译。对COVID-19患者的不同研究表明,由于NK细胞的衰竭,NK细胞的数量和功能显着减少。在这篇综述中,我们总结了目前对NK细胞如何对SARS-CoV-2感染作出反应的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Natural killer cell exhaustion in SARS-CoV-2 infection.

Natural killer cell exhaustion in SARS-CoV-2 infection.

At the end of 2019, an outbreak of a severe respiratory disease occurred in Wuhan China, and an increase in cases of unknown pneumonia was alerted. In January 2020, a new coronavirus named SARS-CoV-2 was identified as the cause. The virus spreads primarily through the respiratory tract, and lymphopenia and cytokine storms have been observed in severely ill patients. This suggests the existence of an immune dysregulation as an accompanying event during a serious illness caused by this virus. Natural killer (NK) cells are innate immune responders, critical for virus shedding and immunomodulation. Despite its importance in viral infections, the contribution of NK cells in the fight against SARS-CoV-2 has yet to be deciphered. Different studies in patients with COVID-19 suggest a significant reduction in the number and function of NK cells due to their exhaustion. In this review, we summarize the current understanding of how NK cells respond to SARS-CoV-2 infection.

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来源期刊
Innate Immunity
Innate Immunity 生物-免疫学
CiteScore
7.20
自引率
0.00%
发文量
20
审稿时长
6-12 weeks
期刊介绍: Innate Immunity is a highly ranked, peer-reviewed scholarly journal and is the official journal of the International Endotoxin & Innate Immunity Society (IEIIS). The journal welcomes manuscripts from researchers actively working on all aspects of innate immunity including biologically active bacterial, viral, fungal, parasitic, and plant components, as well as relevant cells, their receptors, signaling pathways, and induced mediators. The aim of the Journal is to provide a single, interdisciplinary forum for the dissemination of new information on innate immunity in humans, animals, and plants to researchers. The Journal creates a vehicle for the publication of articles encompassing all areas of research, basic, applied, and clinical. The subject areas of interest include, but are not limited to, research in biochemistry, biophysics, cell biology, chemistry, clinical medicine, immunology, infectious disease, microbiology, molecular biology, and pharmacology.
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