微波辅助聚甲基乙烯醚-共马来酸酐-牛血清白蛋白生物偶联物的合成。

Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2012-12-01 Epub Date: 2012-04-30 DOI:10.3109/10731199.2012.678942

Mesut Karahan, Sevecen Tuğlu, Zeynep Mustafaeva

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引用次数: 4

摘要

以1-乙基-3-(3-二甲氰胺-丙基)盐酸碳二亚胺为交联剂，通过微波辅助和常规方法合成了水溶性聚(甲基乙烯醚-共马来酸酐)共聚物-牛血清白蛋白生物偶联物，并采用排粒径层析和高效液相层析对其进行了表征。排除粒径色谱和高效液相色谱结果表明，微波辅助合成的生物偶联物比常规方法更稳定，效率更高。用微波辅助法将反应时间从17小时缩短到15分钟。

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Synthesis of microwave-assisted poly(methyl vinyl ether-co-maleic anhydride)-bovine serum albumin bioconjugates.

The water-soluble poly(methyl vinyl ether-co-maleic anhydride) copolymer-bovine serum albumin bioconjugates were synthesized in the presence of 1-ethyl-3-(3-dimetilamino-propyl) carbodiimide hydrochloride as cross-linking agents via microwave-assisted and conventional methods and characterized by size-exclusion chromatography and high-performance liquid chromatography. According to size-exclusion chromatography and high-performance liquid chromatography results, the bioconjugates synthesized in the microwave-assisted method are more stable and efficient than the conventional method. The reaction time is shortened from 17 hours to 15 minutes by means of the microwave-assisted method.

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来源期刊

Artificial cells, blood substitutes, and immobilization biotechnology 工程技术-材料科学：生物材料

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审稿时长

6-12 weeks