聚合人胎盘血红蛋白对失血性休克模型大鼠血流动力学参数和心功能的影响。

Artificial cells, blood substitutes, and immobilization biotechnology Pub Date : 2012-08-01 Epub Date: 2012-03-13 DOI:10.3109/10731199.2012.663384

Tao Li, Yongxian Jiang, Zhenyu Zhang, Sisi Zhang, Wei Wu, Daqin Liao, Yanfang Chen, Chengmin Yang, Xuewen Xu, Jin Liu

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引用次数: 4

摘要

为了研究聚合人胎盘血红蛋白(PolyPHb)是否能改善失血性休克后的血流动力学参数恢复和心功能，我们将平均动脉压(MAP)维持30 mmHg 60min。然后，随机给大鼠灌血(HES)、出血(全血)或PolyPHb (PolyPHb)进行复苏。PolyPHb组的MAP有明显改善，但仍低于全血组。同时，PolyPHb组的心功能和酶释放量与HES组相似。因此，我们的研究结果表明，在失血性休克中，PolyPHb可适度改善血流动力学恢复，但对心脏保护作用很小。

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Effect of polymerized human placenta hemoglobin on hemodynamic parameter and cardiac function in a rat hemorrhagic shock model.

To investigate whether polymerized human placenta hemoglobin (PolyPHb) improved hemodynamic parameter recovery and cardiac function after hemorrhagic shock, a mean arterial pressure (MAP) of 30 mmHg was maintained for 60min. Then, all the rats were randomly resuscitated with hetastarch (HES), shed blood (Whole Blood), or PolyPHb (PolyPHb). The MAP was greatly improved by PolyPHb, but it was still lower than that of the Whole Blood group. Meanwhile, the cardiac function and enzyme releases in the PolyPHb group were similar to the HES group. Therefore, our findings suggest that PolyPHb moderately improved hemodynamic recovery and provided little cardioprotective effect in hemorrhagic shock.

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来源期刊

Artificial cells, blood substitutes, and immobilization biotechnology 工程技术-材料科学：生物材料

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6-12 weeks