多发性骨髓瘤的溶瘤病毒治疗:过去、现在和未来。

Bone Marrow Research Pub Date : 2011-01-01 Epub Date: 2011-05-10 DOI:10.1155/2011/632948
Chandini M Thirukkumaran, Don G Morris
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引用次数: 14

摘要

多发性骨髓瘤(MM)是一种b细胞恶性肿瘤,目前认为是无法治愈的。尽管最近批准了新的靶向治疗方法,如来那度胺和硼替佐米,但大多数MM患者的复发强调需要有效且耐受性良好的治疗方法来治疗这种致命疾病。近年来,溶瘤病毒作为癌症治疗手段的使用引起了极大的兴趣,目前正处于激烈的临床研究中。自然发生的和工程化的DNA和RNA病毒已被研究作为几种实体和血液系统恶性肿瘤的临床前治疗方式。目前,只有一种基因修饰的麻疹病毒正在进行MM的人体临床试验。从该试验和其他临床试验中获得的信息将指导溶瘤病毒作为MM抗癌药物的临床应用。本文及时概述了溶瘤病毒治疗MM的历史以及未来优化该疾病病毒治疗的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oncolytic virotherapy for multiple myeloma: past, present, and future.

Multiple myeloma (MM) is a B-cell malignancy that is currently felt to be incurable. Despite recently approved novel targeted treatments such as lenalidomide and bortezomib, most MM patients' relapse is emphasizing the need for effective and well-tolerated therapies for this deadly disease. The use of oncolytic viruses has garnered significant interest as cancer therapeutics in recent years, and are currently under intense clinical investigation. Both naturally occurring and engineered DNA and RNA viruses have been investigated preclinically as treatment modalities for several solid and hematological malignancies. Presently, only a genetically modified measles virus is in human clinical trials for MM. The information obtained from this and other future clinical trials will guide clinical application of oncolytic viruses as anticancer agents for MM. This paper provides a timely overview of the history of oncolytic viruses for the treatment of MM and future strategies for the optimization of viral therapy for this disease.

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