天冬氨酸-羟化酶在早期乳腺癌中的预后价值。

IF 2.3 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

International Journal of Biological Markers Pub Date : 2022-09-01 Epub Date: 2022-06-20 DOI:10.1177/03936155221108412

Paola Barboro, Alessandra Rubagotti, Silvia Poddine, Federica Grillo, Luca Mastracci, Francesco Boccardo

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引用次数: 0

摘要

目的:天冬氨酸β -羟化酶(ASPH)是一种参与癌症进展的跨膜蛋白，已被证明在几种实体瘤中预示着较差的预后。本研究的目的是进一步探讨ASPH在早期乳腺癌中的预后价值。方法:采用免疫组化方法对153例乳腺癌患者进行长期随访，研究ASPH表达与临床病理特征、全因死亡率和乳腺癌特异性死亡率的相关性。使用了适当的统计数据。结果:ASPH与全因死亡率和乳腺癌特异性死亡率呈负相关。结论:本队列研究结果支持ASPH在早期乳腺癌中的预后价值。

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The prognostic value of aspartate beta-hydroxylase in early breast cancer.

Purpose Aspartate beta-hydroxylase (ASPH) is a transmembrane protein involved in cancer progression, which has been shown to imply a worse prognosis in several solid tumors. The aim of the present study was to further investigate the prognostic value of ASPH in early breast cancer. Methods ASPH expression was investigated through immunohistochemistry in a cohort of 153 breast cancer patients with long-term follow-up, and correlated with clinical–pathological features plus all-cause and breast-cancer-specific mortality. Appropriate statistics were utilized. Results ASPH negatively correlated with all-cause and breast-cancer-specific mortality. Conclusions The results of this cohort study support the prognostic value of ASPH in early breast cancer.

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来源期刊

International Journal of Biological Markers 医学-生物工程与应用微生物

CiteScore

4.10

自引率

0.00%

发文量

期刊介绍： IJBM is an international, online only, peer-reviewed Journal, which publishes original research and critical reviews primarily focused on cancer biomarkers. IJBM targets advanced topics regarding the application of biomarkers in oncology and is dedicated to solid tumors in adult subjects. The clinical scenarios of interests are screening and early diagnosis of cancer, prognostic assessment, prediction of the response to and monitoring of treatment.