gaba作用药物对吗啡致大鼠热疗的影响。

Methods and findings in experimental and clinical pharmacology Pub Date : 2010-07-01 DOI:10.1358/mf.2010.32.6.1514688

R Nikolov

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引用次数: 8

摘要

GABA (γ -氨基丁酸)是神经系统中一种主要的抑制性神经递质，参与哺乳动物的体温调节。本研究探讨了gaba能神经传递增强药物对吗啡诱导的清醒大鼠热疗模型的影响。我们用体温测定来检验gaba作用药物对吗啡诱导的热疗的影响。在大鼠中，低剂量的吗啡通过腹腔注射产生明显的体温升高，经gaba作用的药物预处理后明显减弱。这些结果表明在一个复杂的体温调节过程中存在阿片能- gaba能相互作用。

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Influence of GABA-acting drugs on morphine-induced hyperthermia in rats.

A major inhibitory neurotransmitter of the nervous system, GABA (gamma-aminobutyric acid), is involved in mammalian thermoregulation. The present study investigated the influence of GABAergic neurotransmission-enhancing drugs, in a model of morphine-induced hyperthermia in conscious rats. We used body temperature assays to examine the effects of GABA-acting drugs on morphine-induced hyperthermia. In rats, low doses of morphine injected i.p. produced significant hyperthermia in a body temperature assay that was significantly attenuated upon pretreatment with GABA-acting drugs. These results suggest the existence of opioidergic-GABAergic interactions in a complex process of thermoregulation.

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来源期刊

Methods and findings in experimental and clinical pharmacology 医学-药学

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>12 weeks