microrna在运动免疫学中有作用吗?对当前文献和未来发展的概述。

IF 3.5 4区 医学 Q2 IMMUNOLOGY
Exercise Immunology Review Pub Date : 2010-01-01
Barbara Wessner, Laura Gryadunov-Masutti, Harald Tschan, Norbert Bachl, Erich Roth
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引用次数: 0

摘要

随着microRNAs (miRNAs)的发现,几年前引入了一种特殊的调节基因表达的方法。miRNA的功能是使特定的信使RNA转录物失活,导致相应蛋白质的消耗,因此计算研究表明,大约三分之一的动物基因可能是miRNA的靶点。最近的出版物强调了mirna在调节免疫反应中的作用。本文的目的是综述miRNA的生物发生和功能,说明它们对先天和适应性免疫系统的影响,展示骨骼肌可塑性和炎症的调节,最后提出它们在运动免疫学领域的可能作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is there a role for microRNAs in exercise immunology? A synopsis of current literature and future developments.

With the discovery of microRNAs (miRNAs), an exceptional means of regulating gene expression was introduced a few years ago. MiRNAs function to inactivate specific messenger RNA transcripts leading to depletion of the corresponding protein, whereby computational studies have shown that about one third of all animal genes might be miRNA targets. Recent publications highlight the involvement of miRNAs in regulating the immune response. The aim of this review is to provide an overview of miRNA biogenesis and function, to illustrate their impact on both the innate as well as the adaptive immune system, to show the regulation of skeletal muscle plasticity and inflammation, and finally to present their possible role within the field of exercise immunology.

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来源期刊
Exercise Immunology Review
Exercise Immunology Review 医学-免疫学
CiteScore
16.00
自引率
0.00%
发文量
7
期刊介绍: Exercise Immunology Review (EIR) serves as the official publication of the International Society of Exercise and Immunology and the German Society of Sports Medicine and Prevention. It is dedicated to advancing knowledge in all areas of immunology relevant to acute exercise and regular physical activity. EIR publishes review articles and papers containing new, original data along with extensive review-like discussions. Recognizing the diverse disciplines contributing to the understanding of immune function, the journal adopts an interdisciplinary approach, facilitating the dissemination of research findings from fields such as exercise sciences, medicine, immunology, physiology, behavioral science, endocrinology, pharmacology, and psychology.
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