[Ezrin与诱导型一氧化氮合酶在涎腺多形性腺瘤恶性增殖中的作用]。

You-Yuan Wang, Wei-Liang Chen, Wei-Xiong Zhang, Zhi-Bao Bai, Zhi-Quan Huang, Jin-Song Li
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引用次数: 4

摘要

背景与目的:Ezrin和诱导型一氧化氮合酶(iNOS)可能在调节肿瘤的增殖、侵袭和转移中发挥重要作用。本研究旨在探讨Ezrin和iNOS的表达及其与涎腺多形性腺瘤(PA)恶性增殖的关系。方法:采用免疫组化方法检测普通型(40例)、活动性(25例)和恶性(11例)多形性腺瘤中Ezrin、iNOS和核Ki-67抗原的表达。结果:Ezrin、iNOS在普通型、活动性和恶性多形性腺瘤中的表达逐渐升高(p)。结论:Ezrin、iNOS过表达可促进唾液腺多形性腺瘤的增殖和恶性转化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Ezrin and inducible nitric oxide synthase in malignant proliferation of salivary gland pleomorphic adenoma].

Background and objective: Ezrin and inducible nitric oxide synthase (iNOS) may play an important role in regulating tumor proliferation, invasion, and metastasis. This study was to investigate the expression of Ezrin and iNOS and their correlation to malignant proliferation of salivary gland pleomorphic adenoma (PA).

Methods: Expressions of Ezrin, iNOS and nuclear Ki-67 antigen were detected by immunohistochemistry in common type (n=40), active type (n=25) and malignant (n=11) pleomorphic adenoma.

Results: Expressions of Ezrin, iNOS in common type, active type and malignant pleomorphic adenoma were gradually increased (P<0.05). There was a significant positive correlation between the expression of Ezrin and iNOS (P<0.05). Ki-67 proliferation index (Ki-67 PI) was increased with the increasing of Ezrin and iNOS expressions (P<0.05).

Conclusion: Overexpression of Ezrin and iNOS may promote proliferation and malignant transformation of salivary gland pleomorphic adenoma.

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