Dm nxf1/sbr基因影响雌性黑腹果蝇减数分裂纺锤体的形成。

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology Pub Date : 2009-01-01 Epub Date: 2009-09-25 DOI:10.1007/s10577-009-9046-x

Elena V Golubkova, Ekaterina G Markova, Anton V Markov, Elina O Avanesyan, Seppo Nokkala, Ludmila A Mamon

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引用次数: 11

摘要

黑腹果蝇(Drosophila melanogaster)的小刷毛(small bristles, sbr)基因属于参与mRNA核输出的核输出因子(nuclear export factor, NXF)基因家族。在减数分裂过程中，携带多种Dm nxf1/sbr基因突变等位基因组合的雌性果蝇表现出分裂纺锤体断裂和中期板染色体错位。sbr(5) /+雌性减数分裂的特征是在第一次细胞分裂时形成三极纺锤体。根据测序结果，sbr (5) (l(1)K4)致死等位基因缺失492个核苷酸。在SBR(5)蛋白中，由于缺失而丢失的146个氨基酸中有57个属于ntf2样结构域。

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Dm nxf1/sbr gene affects the formation of meiotic spindle in female Drosophila melanogaster.

The small bristles (sbr) gene of Drosophila melanogaster belongs to the family of nuclear export factor (NXF) genes that participate in mRNA nuclear export. During meiosis, females of Drosophila melanogaster that carry various combinations of mutant alleles of the Dm nxf1/sbr gene exhibit disruption of the division spindle and misalignment of chromosomes at the metaphase plate. Meiosis of sbr ( 5 ) /+ females is characterized by the formation of tripolar spindles during the first cell division. According to the sequencing results, the sbr ( 5 ) (l(1)K4) lethal allele is a deletion of 492 nucleotides. In SBR(5) protein, 57 of the 146 amino acids that have been lost by deletion belong to the NTF2-like domain.

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Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology

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