塔克林类似物构效关系的研究:电子拓扑方法。

Q2 Pharmacology, Toxicology and Pharmaceutics

Open Medicinal Chemistry Journal Pub Date : 2008-08-06 DOI:10.2174/1874104500802010075

Murat Saracoglu, Fatma Kandemirli

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引用次数: 9

摘要

在这项研究中，我们利用电子拓扑方法(ETM)研究了一类与他林(9-氨基-1,2,3,4-四氢吖啶)和11 h -茚-[1,2-b]-喹啉-10-乙胺相关的乙酰胆碱抑制剂的结构-活性关系，四环他林类似物是目前用于治疗AD的药物。利用ETM分析了活性和非活性化合物的特异性分子片段。试验结果表明，ETM对研究序列的活性和不活性具有较高的预测能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The investigation of structure-activity relationships of tacrine analogues: electronic-topological method.

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The investigation of structure-activity relationships of tacrine analogues: electronic-topological method.

In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H-Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently in use for the treatment of the AD. Molecular fragments being specific for active and inactive compounds were revealed by using ETM. The result of testing showed the high ability of ETM in predicting the activity and inactivity in investigated series.

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来源期刊

Open Medicinal Chemistry Journal Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.40

自引率

0.00%

发文量