Robin M McAllen, Anthony D Shafton, Bradford O Bratton, David Trevaks, John B Furness
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引用次数: 0
摘要
迷走神经刺激被广泛用于治疗，但所激活的纤维群往往不为人知。目的：建立一个简单的方案来确定迷走神经 A、B 和 C 纤维的刺激阈值：方法：用 0.1 毫秒脉冲刺激自主呼吸的麻醉大鼠完整的左或右颈迷走神经。记录心率和呼吸率对迷走神经刺激的反应。随后在远端切断迷走神经，记录对相同刺激的大量动作电位：结果：在实验确定的强度下，以 50 赫兹刺激 2 秒或 2 赫兹刺激 10 秒，发现 A、B 和 C 纤维阈值与呼吸和心率变化有关：结论：我们的简单方案可在体内区分迷走 A、B 和 C 纤维阈值。
Calibration of thresholds for functional engagement of vagal A, B and C fiber groups in vivo.
Vagal nerve stimulation is widely used therapeutically but the fiber groups activated are often unknown.
Aim: To establish a simple protocol to define stimulus thresholds for vagal A, B and C fibers.
Methods: The intact left or right cervical vagus was stimulated with 0.1 ms pulses in spontaneously breathing anesthetized rats. Heart and respiratory rate responses to vagal stimulation were recorded. The vagus was subsequently cut distally, and mass action potentials to the same stimuli were recorded.
Results: Stimulating at either 50 Hz for 2 s or 2 Hz for 10 s at experimentally determined strengths revealed A, B and C fiber thresholds that were related to respiratory and heart rate changes.
Conclusion: Our simple protocol discriminates vagal A, B and C fiber thresholds in vivo.
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