衰老伴HIV的生物标志物及临床指标。

Q2 Medicine

Interdisciplinary topics in gerontology and geriatrics Pub Date : 2017-01-01 Epub Date: 2016-11-22 DOI:10.1159/000448543

Kathleen V Fitch, Meghan Noonan Feldpausch, Sara E Dolan Looby

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引用次数: 7

摘要

HIV感染可能会增强影响通常与衰老相关的过早临床指标发展的特定生物标志物。因此，随着人口老龄化，预测艾滋病毒感染者的死亡率结果极为重要。本章描述了与艾滋病毒炎症、凝血和免疫激活相关的生物标志物，并回顾了特定生物标志物与艾滋病毒感染者合并症发展之间的关系。还讨论了纳入与艾滋病毒感染相关的特定生物标志物的措施，旨在预测艾滋病毒感染者的死亡结果。

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Biomarkers and Clinical Indices of Aging with HIV.

HIV infection may potentiate specific biomarkers that influence the development of premature clinical indices commonly associated with aging. Therefore, predicting mortality outcomes in people living with HIV is extremely important as this population ages. This chapter describes biomarkers associated with inflammation, coagulation, and immune activation in HIV, and reviews the association between specific biomarkers and the development of co-morbid conditions in individuals with HIV. Measures that incorporate specific biomarkers related to HIV infection, designed to predict mortality outcomes in individuals with HIV, are also discussed.

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来源期刊

Interdisciplinary topics in gerontology and geriatrics Medicine-Geriatrics and Gerontology

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期刊介绍： At a time when interest in the process of aging is driving more and more research, ''Interdisciplinary Topics in Gerontology and Geriatrics'' offers investigators a way to stay at the forefront of developments. This series represents a comprehensive and integrated approach to the problems of aging and presents pertinent data from studies in animal and human gerontology. In order to provide a forum for a unified concept of gerontology, both the biological foundations and the clinical and sociological consequences of aging in humans are presented. Individual volumes are characterized by an analytic overall view of the aging process, novel ideas, and original approaches to healthy aging as well as age-related functional decline.