RNA病毒和cGAS-STING通路:重塑我们对先天免疫感知的理解

IF 5.7 2区 医学 Q1 VIROLOGY
Laurence G Webb , Ana Fernandez-Sesma
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引用次数: 32

摘要

在过去的十年中,人们对环GMP-AMP合成酶(cGAS)和干扰素基因刺激因子(STING)的细胞质先天免疫感知途径提供了重要的信息。这些发现拓宽了我们对cGAS-STING通路与自噬、程序性细胞死亡、rig - i样受体(RLR)信号传导、DNA非依赖性干扰素诱导以及该通路如何响应RNA病毒感染的相互联系的理解。这些进展强调了多个RNA病毒家族如何受到cGAS-STING依赖性i型干扰素(IFN-I)诱导的限制,并反过来具有抑制机制。在这里,我们回顾了最近关于cGAS-STING通路如何以及为什么对RNA病毒感染做出反应的发现,以及cGAS-STING先天免疫感知通路的RNA病毒对抗的新发现,并试图为这种DNA感知通路对多种RNA病毒的限制有多重要的思维转变提供背景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
RNA viruses and the cGAS-STING pathway: reframing our understanding of innate immune sensing

The past decade has provided critical information about the cytoplasmic innate immune sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING). These discoveries have broadened our understanding of the interconnectedness of the cGAS-STING pathway with autophagy, programmed cell death, Rig-I-like receptor (RLR) signaling, DNA independent interferon induction, and how this pathway responds to RNA virus infection. These advances highlight how multiple families of RNA viruses are restricted by and in turn have mechanisms to inhibit cGAS-STING dependent type-I interferon (IFN-I) induction. Here we review recent discoveries of how and why the cGAS-STING pathway responds to infection with RNA viruses, novel findings of RNA viral antagonism of the cGAS-STING innate immune sensing pathway, and attempt to provide context for a shift in thinking as to how critical this DNA sensing pathway is for the restriction of a wide range of RNA viruses.

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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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