Mohammad Ashraf, Mohamed Abdelsadg, Athanasios Grivas
{"title":"多形性胶质母细胞瘤的分子特征与脑室下区的关系。","authors":"Mohammad Ashraf, Mohamed Abdelsadg, Athanasios Grivas","doi":"10.1080/02688697.2021.2024144","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the relationship between the molecular characteristics of glioblastoma multiforme (GBM) and the subventricular zone (SVZ).</p><p><strong>Material and methods: </strong>Eligible patients had their data anonymously collected from an institutional database, including age, sex, preoperative performance status, the extent of tumour resection, anatomical location, <i>IDH</i> mutation and <i>MGMT</i> methylation status. An Institutional picture archiving and communications system was used for volumetric and morphometric analysis. All measurements were made on T1-weighted magnetic resonance images with gadolinium contrast enhancement. <i>IDH</i> wild-type and mutant GBMs were stratified by <i>MGMT</i> methylation status. The relationship between tumour volume, distance from the tumour's enhancing edge and the tumour's geometric centre to the SVZ and their molecular characteristics were assessed.</p><p><strong>Results: </strong>Fifty <i>IDH</i> wild-type GBMs were studied. Twenty-three were <i>MGMT</i> methylated, Twenty-seven were unmethylated. <i>IDH</i> wild-type <i>MGMT</i> methylated GBMs were significantly associated with a tumour's enhancing boundary being contiguous to the SVZ (<i>P</i> < 0.001). Ninety percent of tumours contiguous to the SVZ were wild-type methylated (<i>n</i> = 18) and 10% were unmethylated (<i>n</i> = 2). Mean GBM geometric centre distance to SVZ was significantly less for methylated wild-type GBMs compared to unmethylated (<i>P</i> = 0.025) and median GBM distance from the tumour's edge of enhancement to the SVZ was significantly shorter in methylated tumours compared to unmethylated (<i>P</i> < 0.001). Mean and median distances to SVZ from the edge of enhancement was 3.8 millimetres (mm) and 0 mm, respectively, for wild-type methylated GBMs, while for unmethylated wild-types, 14.6 mm, and 12.5 mm. There was no anatomical localisation of <i>IDH</i> wild-type GBMs by <i>MGMT</i> methylation status to a cerebral hemisphere or lobe.</p><p><strong>Conclusion: </strong><i>IDH</i> wild-type GBMs contiguous to the SVZ are highly likely to be <i>MGMT</i> methylated. Replication by further studies is required to affirm our results and conclusion.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relationship between molecular characteristics of glioblastoma multiforme and the subventricular zone.\",\"authors\":\"Mohammad Ashraf, Mohamed Abdelsadg, Athanasios Grivas\",\"doi\":\"10.1080/02688697.2021.2024144\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aims to assess the relationship between the molecular characteristics of glioblastoma multiforme (GBM) and the subventricular zone (SVZ).</p><p><strong>Material and methods: </strong>Eligible patients had their data anonymously collected from an institutional database, including age, sex, preoperative performance status, the extent of tumour resection, anatomical location, <i>IDH</i> mutation and <i>MGMT</i> methylation status. An Institutional picture archiving and communications system was used for volumetric and morphometric analysis. All measurements were made on T1-weighted magnetic resonance images with gadolinium contrast enhancement. <i>IDH</i> wild-type and mutant GBMs were stratified by <i>MGMT</i> methylation status. The relationship between tumour volume, distance from the tumour's enhancing edge and the tumour's geometric centre to the SVZ and their molecular characteristics were assessed.</p><p><strong>Results: </strong>Fifty <i>IDH</i> wild-type GBMs were studied. Twenty-three were <i>MGMT</i> methylated, Twenty-seven were unmethylated. <i>IDH</i> wild-type <i>MGMT</i> methylated GBMs were significantly associated with a tumour's enhancing boundary being contiguous to the SVZ (<i>P</i> < 0.001). Ninety percent of tumours contiguous to the SVZ were wild-type methylated (<i>n</i> = 18) and 10% were unmethylated (<i>n</i> = 2). Mean GBM geometric centre distance to SVZ was significantly less for methylated wild-type GBMs compared to unmethylated (<i>P</i> = 0.025) and median GBM distance from the tumour's edge of enhancement to the SVZ was significantly shorter in methylated tumours compared to unmethylated (<i>P</i> < 0.001). Mean and median distances to SVZ from the edge of enhancement was 3.8 millimetres (mm) and 0 mm, respectively, for wild-type methylated GBMs, while for unmethylated wild-types, 14.6 mm, and 12.5 mm. There was no anatomical localisation of <i>IDH</i> wild-type GBMs by <i>MGMT</i> methylation status to a cerebral hemisphere or lobe.</p><p><strong>Conclusion: </strong><i>IDH</i> wild-type GBMs contiguous to the SVZ are highly likely to be <i>MGMT</i> methylated. Replication by further studies is required to affirm our results and conclusion.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/02688697.2021.2024144\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02688697.2021.2024144","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/18 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Relationship between molecular characteristics of glioblastoma multiforme and the subventricular zone.
Objective: This study aims to assess the relationship between the molecular characteristics of glioblastoma multiforme (GBM) and the subventricular zone (SVZ).
Material and methods: Eligible patients had their data anonymously collected from an institutional database, including age, sex, preoperative performance status, the extent of tumour resection, anatomical location, IDH mutation and MGMT methylation status. An Institutional picture archiving and communications system was used for volumetric and morphometric analysis. All measurements were made on T1-weighted magnetic resonance images with gadolinium contrast enhancement. IDH wild-type and mutant GBMs were stratified by MGMT methylation status. The relationship between tumour volume, distance from the tumour's enhancing edge and the tumour's geometric centre to the SVZ and their molecular characteristics were assessed.
Results: Fifty IDH wild-type GBMs were studied. Twenty-three were MGMT methylated, Twenty-seven were unmethylated. IDH wild-type MGMT methylated GBMs were significantly associated with a tumour's enhancing boundary being contiguous to the SVZ (P < 0.001). Ninety percent of tumours contiguous to the SVZ were wild-type methylated (n = 18) and 10% were unmethylated (n = 2). Mean GBM geometric centre distance to SVZ was significantly less for methylated wild-type GBMs compared to unmethylated (P = 0.025) and median GBM distance from the tumour's edge of enhancement to the SVZ was significantly shorter in methylated tumours compared to unmethylated (P < 0.001). Mean and median distances to SVZ from the edge of enhancement was 3.8 millimetres (mm) and 0 mm, respectively, for wild-type methylated GBMs, while for unmethylated wild-types, 14.6 mm, and 12.5 mm. There was no anatomical localisation of IDH wild-type GBMs by MGMT methylation status to a cerebral hemisphere or lobe.
Conclusion: IDH wild-type GBMs contiguous to the SVZ are highly likely to be MGMT methylated. Replication by further studies is required to affirm our results and conclusion.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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