真菌细胞壁成分调节我们的免疫系统

Q1 Immunology and Microbiology

Cell Surface Pub Date : 2021-12-01 DOI:10.1016/j.tcsw.2021.100067

Benoit Briard , Thierry Fontaine , Thirumala-Devi Kanneganti , Neil A.R. Gow , Nicolas Papon

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引用次数: 8

摘要

侵袭性真菌感染对人类健康仍然是一个严重的问题。总的来说，除了1亿多粘膜感染和10亿多皮肤感染外，它们每年还造成100多万人死亡。为了能够取得进展，了解真菌与免疫系统相互作用的病理生物学是很重要的。在这里，我们重点介绍了真菌细胞壁成分(β-葡聚糖、甘露聚糖、半乳糖半乳聚糖和黑色素)在调节宿主免疫中的关键作用的新进展，并讨论了这些如何为开发免疫调节策略以对抗致命的真菌感染性疾病开辟新的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Fungal cell wall components modulate our immune system

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Fungal cell wall components modulate our immune system

Invasive fungal infections remain highly problematic for human health. Collectively, they account for more than 1 million deaths a year in addition to more than 100 million mucosal infections and 1 billion skin infections. To be able to make progress it is important to understand the pathobiology of fungal interactions with the immune system. Here, we highlight new advancements pointing out the pivotal role of fungal cell wall components (β-glucan, mannan, galactosaminogalactan and melanin) in modulating host immunity and discuss how these open new opportunities for the development of immunomodulatory strategies to combat deadly fungal infectious diseases.

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来源期刊

Cell Surface Immunology and Microbiology-Applied Microbiology and Biotechnology

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

49 days