Epitrack 在区分耐药性癫痫患者手术后记忆力和生活质量变化的特征和模式方面的临床实用性。

IF 1.7 4区 心理学
Applied Neuropsychology-Adult Pub Date : 2024-07-01 Epub Date: 2022-02-11 DOI:10.1080/23279095.2022.2036990
Alejandro Lozano-García, Kevin G Hampel, Antonio Gutiérrez, Vicente Villanueva, Irene Cano-López, Esperanza González-Bono
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引用次数: 0

摘要

目的:评估手术前使用Epitrack筛查工具评估的注意力和执行功能表现是否能区分癫痫患者的记忆和生活质量(QOL)情况,并检测这些变量在手术后的不同变化模式:这是一项纵向研究。77名耐药性癫痫患者(平均年龄=37.91岁)在手术前和手术后一年接受了神经心理学评估。在手术前的评估中使用了专门评估注意力和执行功能的筛查工具 Epitrack,在手术前后则对言语和视觉记忆以及 QOL 进行了评估:Epitrack表现受损的患者与Epitrack表现完好的患者相比,无论在哪个时间点(均为P = 0.04)和可辨别性(P = 0.001),其言语记忆和视觉记忆均较差。而 Epitrack 表现完好的患者则没有出现这种下降。在手术后即时口头回忆能力和辨别能力变化的方差中,Epitrack 总分分别占 13% 和 11% 。Epitrack组在QOL概况或变化方面没有差异,但手术后即时口头回忆能力的改善与手术后QOL的改善有关:我们的研究结果凸显了Epitrack筛查工具在检测不同模式的言语和视觉记忆功能障碍以及预测耐药性癫痫患者手术后言语记忆力下降方面的实用性。手术前Epitrack评分较低的患者手术后记忆力下降的风险似乎更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical utility of Epitrack for differentiating profiles and patterns of post-surgical change in memory and quality of life in patients with drug-resistant epilepsy.

Purpose: To assess whether performance in attention and executive functions evaluated with the Epitrack screening tool before surgery can differentiate memory and quality of life (QOL) profiles, and detect different post-surgical change patterns in these variables in patients with epilepsy.

Methods: This is a longitudinal study. Seventy-seven patients with drug-resistant epilepsy (mean age = 37.91) underwent a neuropsychological assessment before and one year after surgery. Epitrack, a screening tool that exclusively evaluates attention and executive functioning, was administered in the pre-surgical assessment, and verbal and visual memory and QOL were assessed before and after surgery.

Results: Patients with impaired Epitrack performance had poorer verbal and visual memory than those with intact Epitrack performance, regardless of the time point (for all, p < 0.0001). They also showed a post-surgical decline in immediate verbal recall (p = 0.04) and discriminability (p = 0.001). Patients with intact Epitrack performance did not exhibit this decline. Epitrack total score significantly contributed to 13 and 11% of the variance of post-surgical changes in immediate verbal recall and discriminability, respectively. Epitrack groups did not differ in QOL profiles or changes, but post-surgical immediate verbal recall improvements were related to post-surgical QOL improvements.

Conclusion: Our findings underline the utility of Epitrack screening tool to detect different patterns of verbal and visual memory dysfunction, as well as to predict post-surgical verbal memory decline in patients with drug-resistant epilepsy. Patients with lower pre-surgical Epitrack scores appear to be at increased risk for post-surgical memory decline.

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来源期刊
Applied Neuropsychology-Adult
Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY
自引率
11.80%
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>12 weeks
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