HOXD10表达作为肝细胞癌根治性切除的预后因素。

Q2 Medicine

Journal of Buon Pub Date : 2021-09-01

Sujin Park, Sangjoon Choi, Hyun Hee Koh, Cheol Keun Park, Sang Yun Ha

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引用次数: 0

摘要

目的:在包括肝细胞癌(hcc)在内的几种癌症中，HOXD10因表观遗传改变而下调及其作为肿瘤抑制因子的作用已被报道。然而，HOXD10表达在HCC组织样本中的预后作用尚未得到评估。方法:应用免疫组化技术对278例根治性肝癌标本进行HOXD10表达检测，并分析其预测预后的有效性。结果:在82.7%的HCC样本中观察到HOXD10的低表达，并且与年龄增加、肿瘤大小增大和晚期有关。HOXD10是2年以内早期肿瘤复发的独立预测因子。HOXD10低表达患者的无复发生存期(RFS) (p=0.024)和疾病特异性生存期(DSS) (p=0.016)均短于高表达患者。多因素分析证实，HOXD10低表达是较低RFS(风险比1.873,p=0.006)和DSS(风险比2.504,p=0.012)较短的独立预测因子。结论:本研究提供了临床证据，支持HOXD10作为治疗性切除HCC的预后生物标志物，并提示HOXD10也可能是HCC的潜在治疗靶点。

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HOXD10 expression as a prognostic factor for hepatocellular carcinoma treated with curative resection.

Purpose: HOXD10 downregulation resulting from epigenetic changesas well as its role as a tumor suppressor have been reported in several cancers including hepatocellular carcinomas (HCCs). However, the prognostic role of HOXD10 expression in HCC tissue samples has not been evaluated.

Methods: HOXD10 expression was investigated in 278 curatively resected HCC samples using immunohistochemistry and its effectiveness in predicting patient outcome was analyzed.

Results: Low expression of HOXD10 was observed in 82.7% of HCC samples, and this was associated with increased age, large tumor size and advanced stage.HOXD10 was an independent predictive factor for early tumor recurrence at less than 2 years. Patients with low HOXD10 expression showed shorter recurrence-free survival (RFS) (p=0.024) and disease-specific survival (DSS) (p=0.016) than those with high expression. Multivariate analysis confirmed that low HOXD10 expression was an independent predictor of shorter RFS (hazard ratio 1.873, p=0.006) and DSS (hazard ratio2.504, p=0.012) than high HOXD10 expression.

Conclusions: The present study provides clinical evidence supporting the use of HOXD10 as a prognostic biomarker in curatively resected HCCs, and suggests that HOXD10 could also be a potential therapeutic target in HCC.

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来源期刊

Journal of Buon 医学-肿瘤学

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： JBUON aims at the rapid diffusion of scientific knowledge in Oncology. Its character is multidisciplinary, therefore all aspects of oncologic activities are welcome including clinical research (medical oncology, radiation oncology, surgical oncology, nursing oncology, psycho-oncology, supportive care), as well as clinically-oriented basic and laboratory research, cancer epidemiology and social and ethical aspects of cancer. Experts of all these disciplines are included in the Editorial Board. With a rapidly increasing body of new discoveries in clinical therapeutics, the molecular mechanisms that contribute to carcinogenesis, advancements in accurate and early diagnosis etc, JBUON offers a free forum for clinicians and basic researchers to make known promptly their achievements around the world. With this aim JBUON accepts a broad spectrum of articles such as editorials, original articles, reviews, special articles, short communications, commentaries, letters to the editor and correspondence among authors and readers. JBUON keeps the characteristics of its former paper print edition and appears as a bimonthly e-published journal with continuous volume, issue and page numbers.