CD4+ t细胞亚群在皮肤和内脏利什曼病免疫反应中作用的历史回顾

Q2 Biochemistry, Genetics and Molecular Biology
Mohammad Hossein Alimohmmadian, Soheila Ajdary, Fariborz Bahrami
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引用次数: 1

摘要

自20世纪70年代末CD4+ T细胞的Th1和Th2亚群被创造出来以来,人们就开始研究它们的异质性。后来对利什曼病皮肤形式的研究主要集中在利什曼病大感染的实验模型上,使用易感的BALB/c和耐药的C57BL/6小鼠。在21世纪初,调节性t细胞亚群被引入,其在伴随免疫中的作用被提出,负责宿主对再感染的终身抵抗。随后的研究,主要集中在感染的内脏形式,指出IL-17的作用,由CD4+ T细胞的Th17亚群产生,沿着中性粒细胞被证明在保护或加剧感染方面具有重要但模糊的功能。总的来说,目前的知识表明,上述四个亚群可以协调宿主对不同形式的利什曼病的免疫、调节和炎症反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Historic Review of the Role of CD4+ T-Cell Subsets in Development of the Immune Responses against Cutaneous and Visceral Leishmaniases

The heterogeneity of CD4+ T cells has been investigated since the late 1970s, when their Th1 and Th2 subsets were coined. Later studies on the cutaneous form of the Leishmaniasis were focused on the experimental models of Leishmania major infection using the susceptible BALB/c and the resistant C57BL/6 mice. At the early 21st century, the regulatory T-cells subpopulation was introduced and its role in concomitant immunity, responsible for lifelong resistance of the host to the reinfection was proposed. Subsequent studies, mainly focused on the visceral form of the infection pointed to the role of IL-17, produced by Th17 subset of CD4+ T cells that along the neutrophils were shown to have important yet equivocal functions in protection against or exacerbation of the infection. Altogether, the current knowledge indicates that the above four subsets could orchestrate the immune, the regulatory and the inflammatory responses of the host against different forms of leishmaniases.

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来源期刊
Iranian Biomedical Journal
Iranian Biomedical Journal Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
3.20
自引率
0.00%
发文量
42
审稿时长
8 weeks
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