耐药性癫痫的细胞治疗方法。

Journal of epilepsy research Pub Date : 2021-12-31 eCollection Date: 2021-12-01 DOI:10.14581/jer.21021
Pradeep V Mahajan, Swetha Subramanian, Siddhesh C Parab, Sanskruti Mahajan
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引用次数: 0

摘要

耐药癫痫是一个全球性的公共卫生问题。这一类别包括尽管长期服用抗癫痫药物,但仍有癫痫发作的患者。DRE可导致年龄较大的儿童和成人严重残疾和发病,其死亡风险高于一般人群。本报告描述了一例15岁的男性DRE患者,通过自体细胞和高压氧治疗成功治疗。患者接受了两个疗程的细胞治疗,包括来自骨髓、脂肪组织和外周血的细胞,然后是神经物理治疗和氧气治疗。治疗后,患者癫痫发作频率降低,抗癫痫药物剂量减少。治疗一年后的脑电图显示癫痫发作活动有所改善。在这种情况下的结果可能被认为是制定更强大的治疗策略,使用细胞为基础的治疗DRE的初步发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cell-based Therapy Approach for Drug-resistant Epilepsy.

Drug-resistant epilepsy (DRE) is a global public health problem. This category includes patients who continue to experience seizures despite long-term anti-epileptic medications. DRE can lead to severe disability and morbidity in older children and adults and is associated with increased risk of mortality than the general population. This report describes the case of a 15-year-old male patient with DRE successfully managed with autologous cell-based and hyperbaric oxygen therapy. The patient underwent two sessions of cell-based therapy consisting of cells derived from the bone marrow, adipose tissue, and peripheral blood followed by neuro-physiotherapy and oxygen therapy. Post-treatment, the patient experienced decrease in the frequency of seizures and reduction in the dosage of anti-epileptic medications. Electroencephalogram taken one year after the therapy revealed improvement in seizure activity. The outcomes in this case may be considered a preliminary finding in formulating more robust treatment strategies using cell-based therapy for DRE.

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