负载多巴胺修饰的pH敏感水凝胶可有效抑制KRAS突变肺癌细胞的增殖。

IF 3.1 4区医学 Q2 BIOPHYSICS

Journal of Applied Biomaterials & Functional Materials Pub Date : 2022-01-01 DOI:10.1177/22808000211073729

Jun Xu, Chuxi Zhang, Chun Cheng, Jun Yang, Chenxi Li, Xia Liu, Yi Sang

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引用次数: 1

摘要

水凝胶可以在治疗过程中保持较高的局部药物浓度，可能对局部靶向病变区域有用。我们提出了一种由聚乙烯吡咯烷酮(PVP)和壳聚糖组成的pH敏感水凝胶作为治疗KRAS突变型肺癌的新方法。多巴胺的加入改善了该水凝胶的载药和释药效果。我们证明，负载这种多巴胺修饰的pH敏感水凝胶的Tasquinimod比单独Tasquinimod更有效地抑制KRAS突变肺癌细胞的增殖。因此，水凝胶与常规药物的联合治疗可能为肺癌提供一种新的治疗方式。

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A Tasquinomod-loaded dopamine-modified pH sensitive hydrogel is effective at inhibiting the proliferation of KRAS mutant lung cancer cells.

Hydrogels can maintain a high local drug concentration during treatments and may be useful to local targeting diseased areas. We propose a pH sensitive hydrogel consisting of poly-vinylpyrrolidone (PVP) and chitosan as a new treatment method for KRAS mutant lung cancer. Addition of dopamine improved the drug loading and release effects of this hydrogel. We demonstrate that Tasquinimod-loading of this dopamine-modified pH sensitive hydrogel is more effective than Tasquinimod alone for inhibiting the proliferation of KRAS mutant lung cancer cells. Combination of conventional drugs with hydrogels may thus provide a new treatment modality for lung cancer.

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来源期刊

Journal of Applied Biomaterials & Functional Materials BIOPHYSICS-ENGINEERING, BIOMEDICAL

CiteScore

4.40

自引率

4.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials. The areas covered by the journal will include: • Biomaterials / Materials for biomedical applications • Functional materials • Hybrid and composite materials • Soft materials • Hydrogels • Nanomaterials • Gene delivery • Nonodevices • Metamaterials • Active coatings • Surface functionalization • Tissue engineering • Cell delivery/cell encapsulation systems • 3D printing materials • Material characterization • Biomechanics