超越无胚发育不完全突变:半胚形态。

Q2 Dentistry

Monographs in Oral Science Pub Date : 2021-01-01 Epub Date: 2022-01-25 DOI:10.1159/000520764

Alexandre Rezende Vieira

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引用次数: 0

摘要

一些基因的突变可导致无胚性发育不全。这些相同的基因及其通路的其他成员很可能也有助于个体对龋齿和/或牙齿腐蚀磨损的易感性。本章分析了基因的功能，当突变时，这些基因会导致无胚性发育不完美，并讨论了涉及一个或多个基因中的次胚等位基因、甲基化变化和印记障碍的机制如何可能是个体对龋齿和/或糜烂性牙齿磨损的潜在易感性。

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Beyond Amelogenesis Imperfecta Mutations: Hypomorphic Forms.

Mutations in several genes can lead to amelogenesis imperfecta. These same genes and other members of their pathways quite possibly may also contribute to individual susceptibility to dental caries and/or erosive tooth wear. This chapter provides an analysis of the function of the genes which, when mutated, cause amelogenesis imperfecta and discusses how mechanisms involving hypomorphic alleles in one or more genes, methylation changes, and imprinting disorders could be underlying individual susceptibility to dental caries and/or erosive tooth wear.

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来源期刊

Monographs in Oral Science Medicine-Medicine (all)

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： For two decades, ‘Monographs in Oral Science’ has provided a source of in-depth discussion of selected topics in the sciences related to stomatology. Senior investigators are invited to present expanded contributions in their fields of special expertise. The topics chosen are those which have generated a long-standing interest, and on which new conceptual insights or innovative biotechnology are making considerable impact. Authors are selected on the basis of having made lasting contributions to their chosen field and their willingness to share their findings with others.