新生儿乳糜积液的结局:西澳大利亚三级中心20年的经验。

IF 0.7 4区 医学 Q4 IMMUNOLOGY
Lymphology Pub Date : 2021-01-01
A Anvekar, G Athalye-Jape, H Panchal, S Rao, R Kohan
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引用次数: 0

摘要

新生儿乳糜积液是罕见的实体,有限的循证管理。我们对爱德华国王纪念医院和玛格丽特公主医院/珀斯儿童医院收治的20多年来实验室确诊乳糜泻的新生儿进行了回顾性分析。共发现51例乳糜积液患儿。中位胎龄和出生体重分别为35.5周和2620克。包括先天性[27/ 51]和后天性[24/51]病例。产前干预17/22为产前积液,50/51为产后引流。29/51例患儿连续(≥2)次胸部超声监测积液,45/51例患儿多次(≥5)次x线监测积液。机械通气时间、需氧量和住院时间的中位数分别为294.5小时、400小时和49天。39/51接受中链甘油三酯(MCT)饮食,8/51接受奥曲肽。6名婴儿在住院期间死亡。12/19 1年时发育评估正常。与先天性组相比,后天组做了更多的x光片,需要MCT饮食和肌力药物,住院时间更长。使用奥曲肽的新生儿排尿时间、放射检查和免疫球蛋白给药时间更长。综合征相关性、通气时间和氧合时间是死亡率的危险因素。在我们的环境中,新生儿乳糜积液与显著的发病率和死亡率相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Outcomes of neonatal chylous effusions: A 20-year west-Australian tertiary center experience.

Neonatal chylous effusions are rare entity with limited evidence-based management. We conducted a retrospective review of neonates admitted to King Edward Memorial and Princess Margaret/Perth Children's Hospital over 20 years with laboratory-confirmed chylous effusions. A total of 51 infants with chylous effusion were identified. Median gestational age and birth weight were 35.5 weeks and 2620 grams respectively. Congenital [27/ 51] and acquired [24/51] cases were included. Antenatal interventions were performed in 17/22 with antenatal hydrops and 50/51 needed postnatal drains. Effusions were monitored with serial (≥2) chest ultrasounds in 29/51 infants and multiple (≥5) x-rays in 45/51 infants. Median duration of mechanical ventilation, oxygen requirement, and hospital stay was 294.5 hours, 400 hours, and 49 days respectively. 39/51 received medium chain triglyceride (MCT) diet while 8/51 received octreotide. Six infants died during hospital stay. 12/19 had normal developmental assessment at one-year. The acquired group had higher number of xrays done, need for MCT diet and inotropes, and hospital stay vs congenital group. Duration of drains, radiological investigations and immunoglobulin administration were higher in neonates who received octreotide. Syndromic association, duration of ventilation and oxygenation were risk factors for mortality. In our setting, neonatal chylous effusions are associated with significant morbidity and mortality.

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来源期刊
Lymphology
Lymphology 医学-免疫学
CiteScore
5.20
自引率
8.00%
发文量
29
审稿时长
3 months
期刊介绍: The Journal contains original articles, special features (see below), and information regarding the International Society of Lymphology. It seeks original papers dealing with clinical and basic studies of the lymphatic system and its disorders including related fields. Articles are accepted for external review and publication on the condition that they are contributed to Lymphology only and that no substantial part has been or will be published elsewhere.
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