MiR-125b-5p通过靶向BMF改善缺氧/再氧诱导的内皮细胞功能障碍和减轻妊娠大鼠子宫灌注压所致的高血压。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2022-05-01 Epub Date: 2022-02-16 DOI:10.1080/10641955.2022.2036753

Haoyu Zheng, Zhou Yu, Hairong Wang, Hongxue Liu, Xiaoqin Chen

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引用次数: 0

摘要

背景与目的:MicroRNA-125b-5p (miR-125b-5p)在妊娠期高血压症状患者中下调。然而，miR-125b-5p在妊娠高血压(PIH)中的作用尚不清楚。方法:对人胎盘微血管内皮细胞(hpmes)进行缺氧复氧(H/R)处理，建立PIH细胞模型。采用降低子宫灌注压(RUPP)手术建立PIH动物模型。结果:MiR-125b-5p通过下调BMF促进H/ r处理的hpmec细胞活力，抑制细胞凋亡。MiR-125b-5p可缓解RUPP大鼠高血压症状，改善妊娠结局。结论:MiR-125b-5p通过下调BMF，改善H/ r诱导的妊娠大鼠HPMEC功能障碍，减轻rupp诱导的高血压。

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MiR-125b-5p ameliorates hypoxia/reoxygenation-induced endothelial cell dysfunction and attenuates reduced uterine perfusion pressure-induced hypertension in pregnant rats via targeting BMF.

Background and purpose: MicroRNA-125b-5p (miR-125b-5p) is downregulated in patients with gestational hypertension signs. However, the role of miR-125b-5p in pregnancy-induced hypertension (PIH) remains unknown.

Methods: The human placental microvascular endothelial cells (HPMECs) have undergone hypoxia and reoxygenation (H/R) treatment to establish PIH cellular model. Rats were performed with reduced uterine perfusion pressure (RUPP) operation to establish PIH animal model.

Results: MiR-125b-5p promoted viability while inhibited the apoptosis of H/R-treated HPMECs by downregulating BMF. MiR-125b-5p alleviated hypertensive symptoms and improved pregnancy outcomes in RUPP rats.

Conclusion: MiR-125b-5p ameliorates H/R-induced HPMEC dysfunction and attenuates RUPP-induced hypertension in pregnant rats by downregulating BMF.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.