{"title":"河马通路参与糖尿病的发展。","authors":"Yaodong Wang, Haitao Yu, Jinchun He","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The Hippo pathway is a complex signaling network that plays an important role in regulating cellular and metabolic tissue processes, as well as in controlling organ size. However, various disorders and dysfunctions caused by disruptions in Hippo signaling harm parental pancreatic islet cells, promote apoptosis of parental cells, and impair insulin secretion -- leading to the occurrence of diabetes. Herein, we review the role of the Hippo pathway in islet offspring cells, as well as in the involvement of mammalian sterile 20 kinase-1 (MST1), large tumor suppressor-1/2 (LATS1/2), merlin, and yes-associated protein (YAP) in disruptions of Hippo signaling that lead to various disorders and the development of diabetes. Finally, we discuss several remaining issues in translating these promising discoveries into unique treatments in the future.</p>","PeriodicalId":11379,"journal":{"name":"Discovery medicine","volume":"31 162","pages":"37-44"},"PeriodicalIF":2.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Involvement of the Hippo Pathway in the Development of Diabetes.\",\"authors\":\"Yaodong Wang, Haitao Yu, Jinchun He\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The Hippo pathway is a complex signaling network that plays an important role in regulating cellular and metabolic tissue processes, as well as in controlling organ size. However, various disorders and dysfunctions caused by disruptions in Hippo signaling harm parental pancreatic islet cells, promote apoptosis of parental cells, and impair insulin secretion -- leading to the occurrence of diabetes. Herein, we review the role of the Hippo pathway in islet offspring cells, as well as in the involvement of mammalian sterile 20 kinase-1 (MST1), large tumor suppressor-1/2 (LATS1/2), merlin, and yes-associated protein (YAP) in disruptions of Hippo signaling that lead to various disorders and the development of diabetes. Finally, we discuss several remaining issues in translating these promising discoveries into unique treatments in the future.</p>\",\"PeriodicalId\":11379,\"journal\":{\"name\":\"Discovery medicine\",\"volume\":\"31 162\",\"pages\":\"37-44\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Discovery medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Discovery medicine","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Involvement of the Hippo Pathway in the Development of Diabetes.
The Hippo pathway is a complex signaling network that plays an important role in regulating cellular and metabolic tissue processes, as well as in controlling organ size. However, various disorders and dysfunctions caused by disruptions in Hippo signaling harm parental pancreatic islet cells, promote apoptosis of parental cells, and impair insulin secretion -- leading to the occurrence of diabetes. Herein, we review the role of the Hippo pathway in islet offspring cells, as well as in the involvement of mammalian sterile 20 kinase-1 (MST1), large tumor suppressor-1/2 (LATS1/2), merlin, and yes-associated protein (YAP) in disruptions of Hippo signaling that lead to various disorders and the development of diabetes. Finally, we discuss several remaining issues in translating these promising discoveries into unique treatments in the future.
期刊介绍：
Discovery Medicine publishes novel, provocative ideas and research findings that challenge conventional notions about disease mechanisms, diagnosis, treatment, or any of the life sciences subjects. It publishes cutting-edge, reliable, and authoritative information in all branches of life sciences but primarily in the following areas: Novel therapies and diagnostics (approved or experimental); innovative ideas, research technologies, and translational research that will give rise to the next generation of new drugs and therapies; breakthrough understanding of mechanism of disease, biology, and physiology; and commercialization of biomedical discoveries pertaining to the development of new drugs, therapies, medical devices, and research technology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
